Bristol-myers Squibb Compnay

Bristol Meyers Squibb Company

Terry Stouch

Philip Michael Sher

Gang Wu

Bruce A Ellsworth

William N Washburn

Wei Meng

Chandra S Ramanathan

Stephen Kohl Doberstein

Alexandra A Nirschl

Mark Cockett

Nicholas J Lodge

Kevin Fitzgerald

Lisa Moore

Rachel M Kindt

Jenny Kopczynski

The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.

Methods of screening for agents that modulate the interaction of RGS and G&#x3b1;q and urinary incontinence

A compound of formula I is provided having the structure wherein Further provided is a method for treating diabetes and related diseases employing the above compound, either alone or in combination with another therapeutic agent.

Lactam glycogen phosphorylase inhibitors and method of use

Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hyperglycemia, impaired glucose tolerance, insulin resistance and hyperinsulinemia), the microvascular complications associated with diabetes (such as retinopathy, neuropathy, nephropathy and delayed wound healing), the macrovascular complications associated with diabetes (cardiovascular diseases such as atherosclerosis, abnormal heart function, myocardial ischemia and stroke), as well as Metabolic Syndrome and its component conditions including hypertension, obesity and dislipidemia (including hypertriglyceridemia, hypercholesterolemia and low HDL), and other maladies such as non-cardiac ischemia, infection and cancer. These novel compounds have the structure or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, R, R, X, Y and Z are defined herein.

2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors

A compound of formula I wherein   Further provided is a method for treating diabetes and related diseases employing a glycogen phosphorylase inhibiting amount of the above compound, either alone or in combination with another therapeutic agent.

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West Windsor, NJ, United States of America

Terry Stouch