Thermogenesis Corporation

Instacool Inc of North America

Terry L Wolf

Philip H Coelho

Pablo Rubinstein

Jerry M Alcone

Richard Franklin Huyser

Jeffery D Arnett

Pete J Menke

Curtis D Mau

Peter Menke

A device for producing fibrinogen includes a platen having a surface configured for heat exchange with a container, which is adhered to the platen by device of a vacuum and heat exchange allowing both cooling and heating to occur along the boundary between the container and the platen. The platen is operatively coupled to a device of rocking the platen about a horizontal axis and the container allows scavenging of a cryoprecipitate fibrinogen from the blood product for subsequent utilization. A method for fabricating fibrinogen is also disclosed, including the steps of receiving blood product in a container having a heat transfer surface thereon, adhering a container to a heat transfer platen, rocking the container and coating the interior of the container with blood product, transferring heat and thereby altering the temperature of the platen, sensing the temperature of the platen and monitoring the platen temperature, and coupling the heat transfer to the temperature sensor and cycling the blood product through a phase change.

Fibrinogen apparatus, method and container

A fibrin glue dispenser including a spring biased rack. The rack spring is a coil spring having substantially linear characteristics along its operating length. The rack spring forces first and second plungers into first and second loaded syringes to dispense thrombin and fibrinogen into first and second exits such that the admixture of the two occurs for forming fibrin glue away from the exists. A dispensing lever can be controlled as to the fibrin glue formation to dispense either drops of fibrin glue or an elongate line of fibrin glue.

Fibrin glue line and dot dispenser

A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

Method and apparatus for cryogenic storage of thermolabile products

An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.

Fibrinogen processing apparatus method and container

A sprayer for dispensing fibrinogen and thrombin to form fibrin glue immediately away from the sprayer to prevent clogging and insure accurate precise metering. The sprayer includes a pistol grip area, a barrel and a trigger which moves a plunger support that captures the plunger of a syringe. One syringe holds thrombin and the other syringe holds fibrinogen. Each syringe communicates with an outlet having an atomizer.

Sprayer for fibrin glue

Fibrinogen processing apparatus, method and container

Rapid cooling or freezing of foodstuffs, perishables or blood products is accomplished by using a thin film membrane to totally envelope the foodstuffs or blood product only during the heat extraction period. This thin film encapsulation system closes around the item and is held tightly to the item by atmospheric and/or hydrostatic pressure. Once the item is encapsulated, low temperature heat transfer fluids are then circulated on the exterior surface of the membrane, thus extracting the heat within the item through the thickness of the membrane. Upon completion of the necessary chilling or freezing, the atmospheric and/or hydrostatic pressure is withdrawn and the chilled or frozen item is extracted.

Rapid cooling through a thin flexible membrane

A method and device for fractionating pouches of cryoprecipitable material including a membrane which provides a barrier within an interior of the device with the membrane receiving the pouches of cryoprecipitable material therewithin. The interior of the device includes a sump having a heat transfer fluid stored therein and maintained at a temperature which is to be achieved by the cryoprecipitable material as it cycles between freezing and thawing. The pouch of material, after placement within the membrane, is exposed (through the membrane) to hydrostatic forces associated with the heat transfer fluid in the sump collapsing the membrane on the pouch while pulsating jets impinge indirectly upon the pouch through the membrane. In this way, as the contents within the pouch change temperature, circulation of the fluid within the pouch occurs for more rapid realization of the cycling target temperatures for the cryoprecipitable material within the pouch. In one form, a single sump includes both a heating and cooling element for cycling the heat transfer fluid. In another form, two separate sumps respectively store 'hot' heat transfer fluid and 'cold' heat transfer fluid for alternate cycling. After plural cycles, the fractionated component of cryoprecipitable material is centrifuged and then separated.

Device for fractionating constituent components of a substance using

A method and device for thawing pouches of frozen transfusion material including a membrane which provides a barrier within an interior of the device with the membrane receiving the pouches of frozen material therewithin. The interior of the device includes a sump having thawing fluid stored therein and maintained at a constant target temperature which is to be achieved by the frozen transfusion material to be thawed. The pouch of material to be thawed, after placement within the membrane, is exposed (through the membrane) to hydrostatic forces associated with the fluid in the sump collapsing the membrane on the pouch while pulsating jets impinge indirectly upon the pouch through the membrane. In this way, as the contents within the pouch thaw, circulation of the fluid within the pouch occurs for more rapid realization of the target temperature for the fluid within the pouch.

Device for thawing frozen transfusion material and method therefore

A thermal transport device having a hollow within which a plasma storage freezer is deployed. The freezer acts as a cold 'battery' by having a eutectic fluid contained therewithin. The freezer is placed in a commercial, powered refrigeration unit for chilling ('charging') the eutectic fluid of the plasma storage freezer to approximately -30.degree. C. The freezer is then deployed within the thermal transport device and sent to a remote locale for collecting blood plasma. Blood plasma is disposed between a central heat sink and lateral heat sinks of the freezer freezing the blood plasma quickly and maintaininig its initial high quality because of negligible time loss for freezing. Ultimately, the device is returned to a commercial powered refrigeration unit for ('recharging') rechilling the eutectic fluid for subsequent reuse.

Growing community of inventors

Placerville, CA, United States of America

Terry L Wolf