Pfizer Corporation

Abbott Laboratories Corporation

Tularik Limited

Other

Bristol-myers Squibb Compnay

Amgen Inc.

Terry J Rosen

Julio Cesar Medina

John A Flygare

Bei Shan

David Louis Clark

John Adams Lowe, Iii

Daniel T Chu

Fumitaka Ito

Masami Nakane

Manoj C Desai

Hiroshi Kondo

Daniel W Norbeck

Kaoru Shimada

Jacob J Plattner

James P Rizzi

Arthur A Nagel

Dennis Michael Godek

Lewin Theophilus Wint

Sally Gut

Hing L Sham

Brian Thomas O'Neill

Thomas J Sowin

Harry R Howard, Jr

Curt S Cooper

Kunio Satake

Steven M Hannick

Richard J Pariza

Masaya Ikunaka

David L Garmaise

The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: 

Pentafluorobenzenesulfonamides and analogs

The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:

The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:

Benzene compounds as antiproliferative and cholesterol lowering agents

The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:

Substituted benzene compounds as antiproliferative and cholesterol lowering action

Quinuclidine derivatives

The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolernia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##

Compounds of the formula ##STR1## wherein R.sup.1 is methoxy and R.sup.2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.

The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I: ##STR1##

Substituted benzylamino nitrogen containing non-aromatic heterocycles

3-Benzylamino-2-phenyl-piperidine derivatives as substance P receptor

Novel processes are disclosed for the stereoselective preparation of substituted piperidine derivatives of the formulae ##STR1## wherein R.sup.1 and R.sup.2 are defined as below, useful as substance P receptor antagonists and in treating diseases mediated by an excess of substance P.

Stereoselective preparation of substituted piperidines

Novel processes are disclosed for the preparation and resolution of substituted piperidines of the formula ##STR1## wherein R.sup.1 and R.sup.2 are defined as below, and related compounds, as well as novel intermediates used in such processes.

Preparation of substituted piperidenes

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Burlingame, CA, United States of America

Terry J Rosen