Eli Lilly and Company

Other

Lilly Industries, Inc.

Terry D Lindstrom

Jeffrey A Dodge

William B Lacefield

Charles Willis Lugar, Iii

Charles A Frolik

Charles David Jones

William J Ross

Stephen Richard Baker

William B Jamieson

Gilbert S Staten

Michael Paul Clay

Gary W Whitaker

Glucopyranoside benzothiophenes

A bowler's dual position wrist and finger control device is disclosed. The device comprises a hand plate and a forearm plate pivotally linked by a double position hinge mechanism. The double position hinge mechanism angularly disposes the hand plate and forearm plate to each other and limits any backward angular movement beyond this limit, thereby restricting the backward movement of a bowler's hand during delivery of a bowling ball. The double position hinge mechanism allows the user to pre-select two such angles of disposition and limitation in the same plane, and to chose between them by positioning a release lever up or down. The invention further discloses the use of finger supports secured to the hand plate to provide additional support for the bowler. In the preferred embodiment the finger supports are laterally pivotable about the hand plate to enable the user to adjust the supports to a comfortable position.

Bowler's dual position wrist and finger control device

Sulfated benzothiophenes of the formula I ##STR1## wherein R.sup.1 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, --OCOO(C.sub.1 -C.sub.6 alkyl), --OCO(C.sub.1 -C.sub.6 alkyl), --OCOAr wherein Ar is phenyl or optionally substituted phenyl, --OSO.sub.2 (C.sub.4 -C.sub.6 straight chain alkyl), or --OSO.sub.3 H; R.sup.2 is R.sup.1, Cl or F; with the proviso that at least one of R.sup.1 or R.sup.2 is --OSO.sub.3 H; R.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; and n is 2 or 3; or a pharmaceutically acceptable salt or solvate thereof.

Sulfated benzothiophene derivatives, methods of use and formulations

A compound of the formula ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.

Novel macrolide, AS-E 136 metabolite, is obtained from the body fluids of animals receiving AS-E 136 or erythromycylamine. Methods for treating infections caused by pathogenic bacteria, especially Gram-positive bacteria, and pharmaceutical compositions containing the metabolite are provided.

Dirithromycin metabolite

There are described compounds of the formula ##STR1## in which either R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 is carboxyl and R.sup.2 is hydrogen, C.sub.3-4 alkenyl or C.sub.1-4 alkyl, and R.sup.3, R.sup.4 and R.sup.5 are each hydrogen, nitro, hydroxyl, carboxyl, carboxyC.sub.1-2 alkoxy, C.sub.3-4 alkenyl, C.sub.1-4 alkyl, C.sub.3-4 alkenyloxy, C.sub.1-4 alkoxy or the group ##STR2## where R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-4 alkyl; and salts and esters thereof. The compounds are indicated for use in the treatment of immediate sensitivity reactions and inflammatory diseases.

Certain aurones and their use in the treatment of allergies

9-(N-alkanoylaminoalkyl)-fluorenes are anti-arrhythmic agents.

Anti-arrhythmic N-alkanoylaminoalkyl fluorenes

9-Carbamoylfluorene derivatives are useful intermediates in a synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorene antiarrhythmic agents.

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Indianapolis, IN, United States of America

Terry D Lindstrom