Warner-lambert Company

Millennium Pharmaceuticals Limited

Terri Stoeber Purchase

Bharat Kalidas Trivedi

John Michael Domagala

Gary Louis Bolton

Joseph P Sanchez

Edward Faith Elslager

Shelly Ann Glase

Rocco Dean Gogliotti

David T Connor

Bruce D Roth

Lawrence D Wise

The present invention relates to novel compounds and medical methods of treatment of inflammation, atherosclerosis, restenosis, and immune disorders especially those associated with lymphocyte or monocyte accumulation such as arthritis and transplant rejection. More particularly, the present invention concerns the use of 2-phenyl benzimidazole derivatives.

2-phenyl benzimidazole derivatives as MCP-1 antagonists

Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.

Isothiazolones and pharmaceutical formulations

Di- and tri-Methoxybenzyl substituted piperazines and piperidines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopamine antagonists and antipsychotic agents.

Substituted piperazines and piperidines as central nervous system agents

Isothiazolones

Isothiazolone compounds

Growing community of inventors

Ann Arbor, MI, United States of America

Terri Stoeber Purchase