Grifols, S.a.

Grifols Therapeutics Inc.

Terri Journigan

Joann Hotta

Brett Buno

Michael Burdick

Danuta Wronska

James D Mellott

A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.

Methods for purification of a virus produced in vitro and clearance assay for the virus

Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.

Method for generating high-titer hepatitis E virus stocks and titration assay for hepatitis E virus

The present invention relates to compositions, methods, and kits for determining the presence or absence of HIV in a sample, in particular for determining HIV-1 group M, HIV-1 group O, and/or HIV-2, in particular for simultaneous determining of HIV-1 group M, HIV-1 group O, and HIV-2.

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Wendell, NC, United States of America

Terri Journigan