Eastman-Kodak Company

Vaccinex, Inc.

Terrence Lee Fisher

Ernest S Smith

Daniel C Maslanka

Maurice Zauderer

Vlade Josif Kordovich

Eric P Hochreiter

Douglas J Pfaff

Richard Salter

Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers. In particular, anti-CD100 monoclonal antibodies have been developed to neutralize CD100.

Anti-CD100 antibodies and methods for using the same

Compositions and methods are provided for treating diseases associated with CD20, including lymphomas, autoimmune diseases, and transplant rejections. Compositions include anti-CD20 antibodies capable of binding to a human CD20 antigen located on the surface of a human CD20-expressing cell, wherein the antibody has increased complement-dependent cell-mediated cytotoxicity (CDC) that is achieved by having at least one optimized CDR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD20 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD20 antibodies.

Methods of treating multiple sclerosis using anti-CD20 antibodies

Anti-CD100 neutralizing antibodies and methods of using the same

Anti-CD100 antibodies and methods of using the same

The invention relates to epitopes of SEMA4D and to binding agents, such as antibodies, that specifically bind to SEMA4D.

Anti-SEMA4D antibodies and epitopes

Isolated polynucleotides are provided which encode antibody VH and VL polypeptides, and anti-CD100 antibodies and antigen-binding fragments thereof. In another aspect, the invention provides a vector comprising a polynucleotide of the invention. In another aspect, the invention provides a host cell comprising the vector of the invention. In another aspect, the invention provides a method of producing an antibody of the invention, e.g., for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers.

Polynucleotides encoding anti-CD100 antibodies or antigen-binding fragments thereof

Anti-CD100 neutralizing neutralizing antibodies and methods of using the same

Compositions and methods are provided for treating diseases associated with CD100, including certain types of cancers, autoimmune diseases, inflammatory diseases including central nervous system (CNS) and peripheral nervous system (PNS) inflammatory diseases, transplant rejections, and invasive angiogenesis. Compositions include anti-CD100 antibodies capable of binding to a soluble human CD100 antigen or a CD100 antigen located on the surface of a human CD100-expressing cell, wherein the antibody has CD100 blocking activity that is achieved by having at least one optimized CDR or FWR engineered within the variable region of the antibody. Compositions also include antigen-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The invention further includes pharmaceutical compositions comprising the anti-CD100 antibodies of the invention, or antigen-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier, and methods of use of these anti-CD100 antibodies.

Human anti-CD100 antibodies

A printing apparatus and method that provides for severing of prints from receiver media being printed. The receiver media is moved in a process direction past plural printing stations and the printing stations are recording images upon the receiver sheet. While printing is occurring a cutting mechanism having one or more cutting elements is operated to cut the receiver media along a transverse direction to separate a previously printed image on the receiver media from a portion of the receiver media being currently printed. The cutting mechanism includes a clamping member located proximate the one or more cutting elements for stopping movement of the receiver sheet downstream of the clamping mechanism to provide for a substantially square cut relative to the process direction of the receiver media.

Single pass multi-color printer with improved cutting apparatus and method

A method of equalizing web-stretching caused by web tensioning in a dye transfer printer that is for use with a donor web having a dye transfer area and opposite edge areas alongside the dye transfer area, includes the steps of heating a dye transfer area to effect a dye transfer from the dye transfer area to a dye receiver, and heating the edge areas alongside the dye transfer area less than the dye transfer area is heated to effect the dye transfer, but sufficiently so that the edge areas may be stretched by tension substantially the same as the dye transfer area may be stretched. If the edge areas alongside a dye transfer area being used in the printer are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver in the printer.

Preventing crease formation in donor web in dye transfer printer that can cause line artifact on print

In a dye transfer printer, a donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in the printer. The longitudinal tension can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head. According to the invention, the resistance of the edge areas relative to the dye transfer areas, to being stretched, is weakened so that the edge areas can be stretched substantially the same as the dye transfer areas. If the edge areas alongside a dye transfer area being used are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver during dye transfer in the printer.

In a dye transfer printer, a donor web having successive dye transfer areas that are used for printing and opposite longitudinal edge areas alongside each one of the dye transfer areas that are not used for printing are wrapped under longitudinal tension about a cylindrical spool core. The dye transfer areas that are wrapped under tension about the spool core are stretched thinner than the two edge areas that are wrapped under tension about the spool core due to their being heated during printing. The spool core is depressible inward at respective portions on which the two edge areas are wrapped under tension and is not depressible at an intermediate portion between the depressible portions on which the thinner transfer areas are wrapped under tension. As a result, a convolution build-up of the edge areas on the spool core will be no more than a convolution build-up of the thinner transfer areas on the spool core. This substantially reduces the likelihood of any creases being created in the dye transfer areas which would cause line artifacts to be printed on a dye receiver.

A donor web having successive dye transfer areas and opposite longitudinal edge areas alongside each one of the dye transfer areas is subjected to a longitudinal tension when the donor web is advanced in a dye transfer printer, which can stretch the dye transfer areas more than the edge areas because the dye transfer areas, but not the edge areas, are heated at a print head in the printer. According to the invention, the edge areas are pre-weakened before the donor web is used in the printer to weaken a resistance of the edge areas, relative to the dye transfer areas, to being stretched so that the edge areas can be stretched substantially the same as the dye transfer areas when the donor web is used in the printer. The edge areas can be pre-weakened, for example, by perforating or piercing them to create holes in them, or by slitting or cutting them to create cuts in them. If the edge areas alongside a dye transfer area being used in the printer are stretched substantially the same as the dye transfer area, the likelihood of any creases being created in the next unused transfer area is substantially reduced. Thus, no line artifacts will be printed on a dye receiver in the printer.

A printer includes a print head for printing from a donor medium to a receiver medium, a platen member for holding the donor medium in a printing relation with the receiver medium at said print head, a pair of steering and drive rollers for feeding the receiver medium from between the steering and drive rollers, and a movable support for the platen member and the steering roller that moves the platen member towards the print head to hold the receiver medium in the printing relation with the donor medium and away from the print head to release the receiver medium from the printing relation with the donor medium and that moves the steering roller to vary a feeding angle at which the receiver medium is fed from between the steering and driver rollers. The support is movable to three positions, a print position in which the platen member is moved towards the print head to hold the receiver medium in the printing relation with the donor medium and the steering roller is moved to change the feeding angle to one for advancing the receiver medium, a feed-only position in which the platen member is moved away from the print head to release the receiver medium from the printing relation with the donor medium and the steering roller is moved to change the feeding angle to one for returning the receiver medium, and an exit position in which the platen member is moved away from the print head farther than in the feed-only position and the steering roller is moved to change the feeding angle to one for exiting the receiver medium.

Growing community of inventors

Rochester, NY, United States of America

Terrence Lee Fisher