University of South Florida

Roskamp Research LLC

Terrence C Town

Michael J Mullan

Jun Tan

Daniel Paris

There is provided a method of modifying vasoactivity by regulating a soluble A&#x3b2; pro-inflammatory pathway. Also provided is a method of modifying inflammatory reactions in microglia and neurons by regulating a soluble A&#x3b2; pro-inflammatory pathway. A method of treating patients with vascular disease by modifying an intracellular soluble A&#x3b2; pro-inflammatory pathway is also provided. A pharmaceutical composition consisting essentially of an effective amount of a soluble A&#x3b2; pro-inflammatory pathway regulator in a pharmaceutically effective carrier is also provided.

Modulation of the phospholipase A2 pathway as a therapeutic

Methods for assessing the risk of developing Alzheimer's Disease (AD), for diagnosing AD, and for measuring the progression of AD in a patient by determining CD45 isoform expression of blood cells obtained from the patient. The methods of the invention include determining CD45 isoform expression by cytometric analysis, quantitative Western immunoblotting, or quantitative RT-PCR or combinations thereof.

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Lutz, FL, United States of America

Terrence C Town