Amgen Inc.

Biovitrum Ab

Teresa L Marshall

Xiaotian Zhu

John Laird Buchanan

Christopher Michael Tegley

David Craig McGowan

Joseph L Kim

Vinod Francis Patel

Jean E Bemis

Frank Kayser

Qingyian Liu

Daniel Elbaum

David M Armistead

Christopher Harold Fotsch

Guolin Cai

Rajiv Sharma

Michael D Bartberger

Qi Huang

Chester Chenguang Yuan

Lucian V DiPietro

Joseph J Nunes

Christopher Neil Farthing

Nianhe Han

Perry M Novak

Stephanie Geuns-Meyer

Randall W Hungate

Aiwen Li

Sarah Lively

Erin F DiMauro

David Joseph St Jean, Jr

Gregory J Habgood

Meredith Williams

Evert Homan

George Moniz

Lars Johansson

Jinqian Liu

Martin Henriksson

Matthew J Frizzle

Eric A Bercot

Stephen J Shuttleworth

William H Buckner

Alexander David Frenkel

Simon A Burkitt

Leticia M Toledo-Sherman

Martin J Harrison

The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-&#x3b2;-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-&#x3b2;-hydroxysteroid dehydrogenase type 1 enzyme.

Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1

The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

Furanopyrimidines

The invention relates to inhibitors of enzymes that bind to ATP or GTP and/or catalyze phosphoryl transfer, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making phosphoryl transferase inhibitor compounds, methods of inhibiting phosphoryl transferase activity, and methods for treating disease or disease symptoms.

Kinase inhibitors

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Stow, MA, United States of America

Teresa L Marshall