Musc Foundation for Research Development

Novici Biotech LLC

Other

Ibio Limited

Terence E Ryan

Hal S Padgett

Carol A Feghali-Bostwick

Matthew McGee

John A Kink

R Barry Holtz

John A Todd

Badr Saeed

Matthew Mcgee

Carol Feghali-Bostwick

Materials and methods for using polypeptides containing fragments and variants of endostatin to treat fibrosis are described herein.

Endostatin fragments and variants for use in treating fibrosis

This document provides materials and methods for producing endostatin fusion polypeptides having anti-fibrotic activity. For example, provided herein are fusion polypeptides having an IgG Fc domain and a portion of human endostatin that can form high molecular weight multimers, as well as methods for producing such fusion polypeptides in plant cells.

Materials and methods for producing endostatin fusion polypeptides in plant cells

An assay for detection of serum antibodies having specificity to hepatitis C viral antigens utilizes the carboxy-terminal 102 amino acids of the c33c region of nonstructural gene 3 of HCV containing substantially all the epitopes of the gene 3 protein. In the preferred embodiment the recombinant 102 amino acid peptide is coated onto a solid support, and incubated in the presence of serum obtained from a patient infected with HCV. The presence of antibodies bound to the antigen coated support is detected in a sandwich format utilizing a second reporter-conjugated antibody.

Epitope mapping of the c33 region of HCV

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Eagleville, PA, United States of America

Terence E Ryan