Virginia Commonwealth University

Center for Innovative Technology

Telih Boyiri

Donald J Abraham

Richmond E Danso-Danquah

Martin K Safo

Michael J Gerber

Gajanan S Joshi

Stephen J Hoffman

Changquing Wang

Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate.

Allosteric inhibitors of pyruvate kinase

Chemical compounds which interact inside the central water cavity of hemoglobin and bridge between the two .alpha. subunits can be used to allosterically modify hemoglobin towards tense and relaxed states. The functional groups employed are aldehydes and carboxylic acids, wherein the aldehydes form covalent bonds (schiff base) with amino acid residues of hemoglobin and the carboxylic acids form ionic bonds with amino acid residues of hemoglobin. Particularly useful compounds within the practice of this invention bond to the n-terminal valine of one .alpha. subunit of hemoglobin, and the lysine 99 and/or arginine 141 of the other .alpha. subunit.

Aldehydic agents for allosteric modification of hemoglobin

Growing community of inventors

Richmond, VA, United States of America

Telih Boyiri