Dexcom, Inc.

Hewlett-packard Company

Hewlett-packard Development Company, L.p.

Ted Tang Lee

Peter C Simpson

Jason M Halac

Jason Mitchell

Ryan Everett Schoonmaker

John Michael Gray

Jeff Jackson

Becky L Clark

John Charles Barry

David A Keller

Kenneth Pirondini

Disha B Sheth

Jonathan Hughes

Matthew D Wightlin

Antoni S Murcia

Jennifer Blackwell

Sean T Saint

Paul V Neale

Sebastian Bohm

Stephen J Vanslyke

Andrew Attila Pal

Maria Noel Brown Wells

Hari Hampapuram

Norman E Pawlowski

Naresh Chandra Bhavaraju

Arturo Garcia

Kenneth R Williams

Daiting Rong

Anna Leigh Davis

Aditya Sagar Mandapaka

Lauren Hruby Jepson

Rui Ma

Jack Pryor

Robert James Boock

Leif N Bowman

James R Petisce

Mark Allan Tapsak

Sebastian Böhm

Shanger Wang

Chris W Dring

Jiong Zou

Kyle Thomas Stewart

David Rego

John Stanley Hayes

Craig Thomas Gadd

Kris Elliot Higley

Neel Narayan Shah

Todd Andrew Newhouse

Minglian Shi

Michael Levozier Moore

Leah Morta Edra

John Patrick Majewski

Zebediah L McDaniel

Vincent Peter Crabtree

Liang Wang

David I-Chun Lee

Alexander Leroy Teeter

Andrew Trinin Dennis

Tod S Heiles

Huashi Zhang

Richard H Lewis

Phong Lieu

Michael K Bowen

B Michael Eckard

Christopher Taylor

Jeff T Suri

Bruce Alan McFadden

Wenjie Lan

Gary L Miller

Thomas G Cocklin

David Sze

Juan Carlos Vives

James Jinwoo Lee

Tim Ray Gackstetter

Devon M Headen

George Vigil

Roger Schneider

Mark A Tapsak

Maria Neol Brown Wells

Disclosed are devices for determining an analyte concentration. The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and an electronics unit operatively connected to the sensor. The electronics unit may be engaged with a housing that may secure the device to a host's skin. In this regard, in one embodiment, the housing may be attached to an adhesive patch that is fastened to the skin of the host.

Analyte sensor

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

Enzyme immobilized adhesive layer for analyte sensors

Various examples described herein are directed to systems, apparatuses, and methods for mitigating break-in in an analyte sensor. An example analyte sensor system comprises an analyte sensor applicator comprising a needle; an analyte sensor comprising at least a working electrode and a reference electrode, the analyte sensor positioned at least partially within a lumen of the needle; and a hydrating agent positioned within the lumen of the needle to at least partially hydrate the needle.

Analyte sensor break-in mitigation

Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

Automatic analyte sensor calibration and error detection

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Pre-connected analyte sensors

Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

Transcutaneous analyte sensor systems and methods

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than &#x2212;50 C.

Membrane layers for analyte sensors

The present disclosure relates to a needle including a wall structure, a cutting edge and a blunt contour. The needle advantageously can be used to deliver a sensor (such as a glucose or other analyte sensor) through an outer skin layer and into a sensor depth in a less invasive way than prior art needles. The size of the cutting edge is balanced against a portion of the distal wall structure that has blunt contours. Thus, the needle is capable of cutting the more durable outer skin layer (first phase) and then progressively stretching open the cut for further advancement into the subcutaneous layer (second phase). When the needle is sufficiently advanced, it is retracted leaving the sensor in a desired position. Early testing has shown a reduction of 'dip and recover' from glucose sensors delivered using the needle.

Needle for transcutaneous analyte sensor delivery

Adhesive pad systems that provide longer lasting adherence of the mounting unit to the host's skin are provided. Some systems include a reinforcing overlay that at least partially covers the adhesive pad. The reinforcing overlay may be removable without disturbing the sensor so that the overlay may be replaceable.

Systems and methods for securing a continuous analyte sensor to a host

Growing community of inventors

San Diego, CA, United States of America

Ted Tang Lee