University of Hawai'i

Eli Lilly and Company

Ted R Norton

Jon S Mynderse

Richard E Moore

Gregory M Patterson

Shoji Shibata

Eiichi Furusawa

Midori Kashiwagi

Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.

Scytophycins-producing Scytonema pseudohofmanni microorganisms

Scytophycins

A novel peptide designated anthopleurin-B, hereinafter also referred to as AP-B, obtained from the sea anemone Anthopleura xanthogrammica is found to possess cardiotonic activity.

Cardiotonic agent

A novel peptide designated anthopleurin-C, hereinafter also referred to as AP-C, obtained from the sea anemone Anthopleura elegantissima is found to possess cardiotonic activity.

A peptide designated anthopleurin-A, hereinafter also referred to as AP-A, obtained from the sea anemone Anthopleura xanthogrammica is found to possess cardiotonic activity.

Growing community of inventors

Honolulu, HI, United States of America

Ted R Norton