Agouron Pharmaceuticals, Inc.

Ted Michael Bleckman

Siegfried Heinz Reich

Stephen Evan Webber

William Henry Romines, Iii

Michael Brennan Wallace

Michael D Varney

Peter Scott Dragovich

Thomas L Little, Jr

Joseph Timothy Marakovits

Robert E Babine

Thomas Jay Prins

Susan Elizabeth Kephart

Ethel S Littlefield

John Attard

Terence R Jones

Cynthia Louise Palmer

Yi Yang

Wesley Kwan Mung Chong

Shao Song Chu

Rohit Kumar Duvadie

Lin Li

Larry Andrew Alegria

Terrence R Jones

Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation

(4-oxo-2-pyrimidinyl)thioalkyl compounds useful as AICARFT inhibitors

Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.

Antipicornaviral compounds and methods for their use and preparation

Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.

Antiproliferative quinazolines

Growing community of inventors

La Jolla, CA, United States of America

Ted Michael Bleckman