Nanyang Technological University

Teck Peng Loh

Jian Xiao

Yu Zhao

Peng Wang

Bengang Xing

Daniel Hartoyo Lukamto

Jiesheng Tian

Jingmei Huang

Ata Abbas

Peng Fei Jackson Koh

There is provided a compound of formula I, having the structure: wherein Rto Rhave the meanings given in the description. 

Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins

The present invention relates to a compound of general Formula (VIII), the compound having a bowl-shaped conformation, its formation and its use in asymmetric catalysis. In Formula (VIII), M is a metal selected from the group consisting of Group 1 to Group 14 metals, lanthanides and actinides; R is one of &#x2014;COOR, &#x2014;RCOOR, &#x2014;RCHO, &#x2014;RCOR, &#x2014;RCONRR, &#x2014;RCOX, &#x2014;ROP(&#x2550;O)(OH), &#x2014;RP(&#x2550;O)(OH)), &#x2014;RC(O)C(R)CRRand RCOC(R)O, wherein R, R, R, R, Rand Rare as defined herein.

Tricyclic chiral compounds and their use in asymmetric catalysis

The invention relates to 3-piperidone compounds, and in particular, to (2S)-phenyl-3-piperidone and its synthesis method. Use of the thus-synthesized 3-piperidone compounds as potent neurokinin-1 (NK1) receptor antagonists is also provided.

3-piperidone compounds and their use as neurokinin-1 (NK1) receptor antagonists

The disclosure provides the use of aryl or heteroaryl boronic acid in the preparation of 5-(hydroxymethyl)fufural (HMF) from saccharides. The aryl or heteroaryl boronic bearing electron-withdrawing groups on the aryl or heteroaryl ring of the boronic acid provided good yields. The disclosure provides a method for preparing HMF from saccharides in the presence of aryl or heteroaryl boronic acid. The disclosure provides a method for converting a saccharide other than fructose in fructose via a dehydrogenation reaction catalyzed by aryl or heteroaryl boronic acid.

Small molecule catalyst for 5-hydroxymethylfurfural production from saccharides

The present invention relates to a compound of general Formula (XX), its formation and its use in asymmetric catalysis. In Formula (XX) R and Rare independently &#x2014;COOR, &#x2014;RCOOR, &#x2014;RCHO, &#x2014;RCOR, &#x2014;RCONRR, &#x2014;RCOX, &#x2014;ROP(&#x2550;O)(OH), &#x2014;RP(&#x2550;O)(OH)), &#x2014;RC(O)C(R)CRRand &#x2014;RCOCOR. In addition, Rmay also be hydrogen. R, Rand Rare independently hydrogen, an aliphatic group with a main chain having 1 to about 20 carbon atoms, an alicyclic group, an aromatic group, an arylaliphatic group or an arylalicyclic group, comprising 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si. Ran aliphatic bridge with a main chain having 1 to about 20 carbon atoms, an alicyclic bridge, an aromatic bridge, an arylaliphatic bridge or an arylalicyclic bridge, comprising 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si, and X is halogen. In Formula (XX) Ris &#x2014;C(OH)RRor &#x2014;COOR, wherein R, Rand Rare independently hydrogen, an aliphatic group with a main chain having 1 to about 20 carbon atoms, an alicyclic group, an aromatic group, an arylaliphatic group or an arylalicyclic group, comprising 0 to about 3 heteroatoms independently selected from the group consisting of N, O, S, Se and Si.

The present invention relates to a method for the synthesis of an &#x3b1; amino acetal, comprising (i) oxidizing a tertiary amine in the presence of a copper catalyst, at least one oxidant and a solvent, or (ii) reacting a secondary amine and an aliphatic aldehyde in the presence of a copper catalyst, at least one oxidant and a solvent.

Method for the synthesis of an amino acetal

The present invention relates to an octahydro biquinoline compound. Provided is also a method of separating the octahydro biquinoline compound into enantiomers. The octahydro biquinoline compound is of the general formula (V): In formula (V) Ris one of H, a protective group and an aliphatic group, with the aliphatic group having a main chain of a length of 1 to about 10 carbon atoms, comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si. Rand Rare independent from one another selected from the group consisting of (i) H, (ii) one of an aliphatic, an alicyclic, an aromatic, an arylaliphatic, and an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si, an ester, a carbonate group, a carbamoyl group and a phosphate ester. Rand Rare independent from one another H, an aliphatic, an alicyclic, an aromatic, an arylaliphatic or an arylalicyclic group comprising 0 to about 6 heteroatoms selected from the group consisting of N, O, S, Se and Si.

Octahydro biquinoline compound

The present invention relates to a cyclization process of forming a multiple ring compound from an isoprenoid compound. The cyclization process involves reacting the isoprenoid compound with an acetal initiator under conditions sufficient to form the multiple ring compound. The isoprenoid compound is contacted with an initiator and optionally with a catalyst. Cyclization occurs by reaction of the initiator with the isoprenoid compound. Cyclic acetal compounds wherein the acetal forms part of 6-membered unsaturated ring are also defined.

Cyclisation process of forming a multiple ring compound

The present invention relates to a cyclization process of forming a multiple ring compound from an isoprenoid compound. The cyclization process involves reacting the isoprenoid compound with an acetal initiator under conditions sufficient to form the multiple ring compound. The isoprenoid compound is contacted with an initiator an optionally with a catalyst. Cyclization occurs by reaction of the initiator with the isoprenoid compound. Cyclic acetal compounds wherein the acetal forms part of 6-membered unsaturated ring are also defined. 

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Singapore, Singapore

Teck Peng Loh