Novartis Ag

Tea Shavlakadze

David Jonathan Glass

Simone Bonazzi

Andrew William Patterson

Silvio Roggo

Manuel Mihalic

Michael Connolly

Michael D Connolly

Patrik Zueger

The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein.

Rapamycin derivatives

The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Growing community of inventors

Cambridge, MA, United States of America

Tea Shavlakadze