The General Hospital Corporation

New England Biolabs, Inc.

Massachusetts Eye and Ear Infirmary

The Rowland Institute for Science

Quadra Logic Technologies, Inc.

Tayyaba Hasan

Michael R Hamblin

Kenneth Trauner

Gerard J Nau

Ulysses W Sallum

Akilan Palanisami

Jerome Gross

Sarika Verma

Nikos Soukos

Anthony H Cincotta

Julia G Levy

Louis Cincotta

Joan W Miller

Barton E Slatko

Ursula Schmidt-Erfurth

Mihaela Skobe

Evangelos S Gradoudas

Bryan Q Spring

Mark D Savellano

Srivalleesha Mallidi

Shazia Khan

Jeremy Foster

Gerard Nau

The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.

Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same

The present disclosure features portable wide field fluorimeter systems, e.g., in the form of low-cost mobile platforms, and methods to perform fluorometric assays to detect a change in fluorescence intensity in liquid samples, e.g., caused by the presence of a target analyte, e.g., a protein, e.g., an enzyme (e.g., &#x3b2;-lactamase) expressed by a target pathogen in a liquid sample in a point-of-care setting. In some implementations, a portable system for detecting a change in fluorescence intensity in a liquid sample includes a microfluidic device, an optical assembly including an emission filter and one or more lenses, and an analyzer device that collects and processes a fluorescent signal for the detection of a target analyte produced by the target pathogen present in the liquid sample.

Portable wide field fluorimeter systems

Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.

Methods of treating and imaging tumor micrometastases using photoactive immunoconjugates

Photoactivatable pesticide compounds and methods for the use thereof in the elimination and detection of pests are provided.

&#x3b2;-lactamase targeted photosensitizer for pesticide and pest detection

One aspect of the present disclosure relates to a device for detecting a target analyte in a liquid sample. The device can comprise a housing. The housing can include an inlet for receiving a liquid sample, an outlet for removing a volume of the liquid sample from the device, a filter associated with the outlet and being sized and dimensioned to retain a target analyte on a surface thereof, and a flow system comprising at least one channel that is in communication with the inlet and the outlet. At least a portion of the at least one channel can be located substantially adjacent the surface of the filter and be shaped and dimensioned to reduce the amount of unreacted fluorescent probe available to create the background interference during detection of the target analyte.

Devices and methods for target analyte detection in liquid samples

A method for measuring differential blood oxygen saturation in a solid tumor is described that includes the steps of obtaining a first oxygenation image of a solid tumor before, during, or immediately after a administration of vascular therapy; obtaining a second oxygenation image of the solid tumor after a devascularization time period; and determining a differential blood oxygen saturation value by comparing the first oxygenation image and the second oxygenation image. The differential blood oxygen saturation value can be compared to a blood oxygen saturation necrosis value to provide a prognosis for tumor recurrence, or to guide of the tumor.

Prediction of tumor recurrence by measuring oxygen saturation

The present invention relates to photosensitizer immunoconjugate compositions and combination therapies for use in cancer related photodynamic treatments and diagnostic methods. Photosensitizer immunoconjugates comprising a photosensitizer conjugated to a tumor-specific and/or tumoricidial antibody and processes for the preparation thereof are described. The use of photosensitizer immunoconjugates (PICs) offers improved photosensitizer delivery specificity for diagnostic and therapeutic applications. Combination therapies to co-localize activated photosensitizer compounds and tumoricidal antibodies in tumor tissues are also described.

Photoimmunotherapies for cancer using combination therapies

Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.

Photosensitizer conjugates for pathogen targeting

The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is associated with an intracellular pathogen by administering, to a subject, a molecular conjugate that includes a photosensitizer (a term used herein to refer to a light activatable compound) and a targeting moiety, the targeting moiety being capable of targeting the conjugate to the intracellular pathogen.

Photosensitizer conjugates for targeting intracellular pathogens

Photosensitzer conjugates for targeting intracellular pathogens

Disclosed is a method for accelerating wound healing in a mammal. The method includes identifying an unhealed wound site or partially-healed wound site in a mammal; administering a photosensitizer to the mammal; waiting for a time period wherein the photosensitizer reaches an effective tissue concentration at the wound site; and photoactivating the photosensitizer at the wound site. The dose of photodynamic therapy is selected to stimulate the production of one or more growth factor by cells at the wound site, without causing tissue destruction.

Acceleration of wound healing by photodynamic therapy

A method of ablating the growth of or eradicating neoplasms in mammals by

Benzophenothiazine and benzoporphyrin dye combination photodynamic

A method of treating a patient who has osteoarthritic disease by administering a therapeutic composition containing a photoactivatable compound, or a precursor thereof, and administering light of a photoactivating wavelength that activates the compound.

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Arlington, MA, United States of America

Tayyaba Hasan