Janssen Pharmaceutica Nv

Ortho-mcneil Pharmaceutical Corp.

3-dimensional Pharmaceuticals, Inc.

Taxiarchis M Georgiadis

Mark R Player

Raymond Joseph Patch

Nand Baindur

Davoud Asgari

Benjamin Brandt

Naresh Chadha

The invention is directed to compounds of Formula II: wherein A, R, R, R, R, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

c-fms kinase inhibitors

The invention is directed to compounds of Formulae I, II and III: wherein A, R, R, R, R, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

C-fms kinase inhibitors

The invention is directed to compounds of Formulae I: wherein A, R, R, R, R, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

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Carmel, IN, United States of America

Taxiarchis M Georgiadis