Ajinomoto Co., Ltd.

Other

Tatyana Viktorovna Leonova

Mikhail Markovich Gusyatiner

Elvira Borisovna Voroshilova

Konstantin Vyacheslavovich Rybak

Yury Ivanovich Kozlov

Takuji Ueda

Aleksandra Yurievna Skorokhodova

Elena Vitalievna Klyachko

Tatyana Abramovna Yampolskaya

Leonid Romanovich Ptitsyn

Vitaly Grigorievich Paraskevov, Legal Representative

Yoshihiko Hara

Vera Georgievna Doroshenko

Sergei Vladimirovich Mashko

Ekaterina Aleksandrovna Slivinskaya

Ekaterina Alekseevna Savrasova

Larisa Gotlibovna Airikh

Valeriy Zavenovich Akhverdian

Yulia Georgievna Rostova

Irina Borisovna Altman

Maria Grigorievna Lunts

Sergey Vasil'evich Smirnov

Svetlana Aleksandrovna Fomina

Marina Evgenievna Sheremet'eva

Mika Moriya

Nelli Isaakovna Zhdanova

Dmitriy Vladimirovich Filippov

Yuri Nagai

Danila Vadimovich Zimenkov

Keiko Noguchi

Andrey Yurievich Gulevich

Vitaly Grigorievich Paraskevov

Ljudmila F Kozyreva

Yury Ivanovich Koslov

There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease.

Method for producing L-amino acids using bacteria of the enterobacteriaceae family

The present invention provides a method for producing L-amino acids, such as L-arginine, L-citrulline, and L-lysine, using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genusor, which has been modified to attenuate expression of one or more genes, such as the pepA, pepB, and pepD genes.

Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family, having attenuated expression of gene(s) encoding peptidase

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of a gene coding for sRNA.

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The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of the ybiV gene.

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of the cpxR gene.

Method for producing L-amino acids using bacteria of the Enterobacteriaceae family

The present invention provides a method for producing a non-aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genusor, which has been modified to attenuate expression of the csrA gene.

L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus, which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid, L-proline or L-arginine, in a medium containing L-isoleucine, to produce and accumulate L-glutamic acid, L-proline or L-arginine in a culture, and collecting L-glutamic acid, L-proline or L-arginine from the culture.

Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine

The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genusor, which has been modified to attenuate expression of the yafA gene.

L-arginine is produced using a bacterium belonging to the genusharboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.

Arginine can be efficiently produced by cultivatingwhich has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate arginine in the medium, and collecting arginine from the medium.

L-Glutamic acid, L-proline or L-arginine is produced by culturing a bacterium belonging to the genus Escherichia, which is L-isoleucine auxotrophic and has ability to produce L-glutamic acid, L-proline or L-arginine, in a medium containing L-isoleucine, to produce and accumulate L-glutamic acid, L-proline or L-arginine in a culture, and collecting L-glutamic acid, L-proline or L-arginine from the culture.

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Moscow, Russia

Tatyana Viktorovna Leonova