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Moskovsky Nauchno-teknichesky Compleks 'mikrochirurgija Glaza'

Tatyana S Amstislavskaya

Irina A Maklakova

Sergey N Bagrov

Sergey V Maslenkov

Svyatoslav N Fyodorov

Svyatoslav N Fedorov

Sergei Nikolayevich Bagrov

Alexei V Osipov

Vladislav T Trofimov

Ophthalmologic collagen coverings derived from animal eyes and a process for preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.

Ophthalmological collagen coverings

Ophthalmologic collagen coverings derived from animal eyes and a process preparing such coverings comprising treatment of a fibrous tunic of an animal eye with an alkali metal hydroxide in a saturated solution of a salt of an alkali metal, followed by neutralization, dissolution in an aqueous solution of an organic acid, purification of the resulting solution of collagen by dialysis against a buffer solution while bringing the solution of collagen to a pH of 4.5 to 7.5 and drying the thus-obtained solution of collagen simultaneously with shaping spherical coverings therefrom.

Opthalmological collagen coverings

A process for producing a collagen-based cross-linked biopolymer is provided in which a collagen solution free of low-molecular impurities is saturated with nitrogen protoxide, its concentration is brought to maximum 80 mass percent and the solution is exposed to an ionizing radiation in a dose of 0.5 to 15 kGy. An implant for hermetization of corneal and scleral wounds involved in eye injuries prepared from said bipolymer has the shape and size that provide for complete hermetization of said wounds. The method for its preparation comprises saturation of a collagen solution free of impurities and having a concentration of 0.2 to 1.3 mass percent, with nitrous oxide, filling of a mould with said solution and its exposure to an ionizing radiation in a dose of 0.5 to 15 kGy. The resultant blank is dried to a moisture content in its biopolymer of 30 to 50 mass percent, whereupon the blank is given the shape and size of a required implant. The method of hermetization of said wounds is carried into effect by introducing the implant shaped as a cylinder with a tapered end, with said end into an operative wound incision, fixing the implant in the wound for 1 or 2 minutes and removal of the implant portion that stands over the corneal or scleral surface.

Process for producing collagen-based cross-linked biopolymer, an implant

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Moscow, Russia

Tatyana S Amstislavskaya