Ajinomoto Co., Ltd.

Tatyana Abramovna Yampolskaya

Leonid Romanovich Ptitsyn

Mikhail Markovich Gusyatiner

Yury Ivanovich Kozlov

Irina Borisovna Altman

Tatyana Viktorovna Leonova

Yulia Georgievna Rostova

Sergey Vasil'evich Smirnov

Natalia Viktorovna Stoynova

Veronika Aleksandrovna Kotliarova

Anna Eugenievna Novikova

Yuri Ivanovich Kozlov

Natalia Sergeevna Eremina

Elena Viktorovna Sycheva

Ekaterina Sergeevna Preobrazhenskaya

Tatyana Aleksandrovna Bachina

Yurgis Antanas Vladovich Iomantas

Elena Georgievna Abalakina

Vsevolod Aleksandrovich Serebryanyy

Boris Mironovich Polanuer

Olga Nikolaevna Mokhova

The present invention provides a method for producing L-amino acid using a bacterium belonging to the family Enterobacteriaceae, particularly a motile bacterium belonging to the genusor, wherein the bacterium has been modified so that expression of at least one gene of the flagella formation and motility cascade is enhanced.

Method for producing an L-amino acid using a bacterium of the family Enterobacteriaceae having enhanced expression of the flagella formation and motility cascade genes

A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine. This acetolactate synthase contains a mutant small subunit encoded by the mutant ilvN gene.

Mutant acetolactate synthase and a method for producing branched-chain L-amino acids

The present invention provides a method for producing an L-amino acid from ethanol using a bacterium of thefamily, wherein the bacterium has been modified to enhance the expression of the ydbK gene.

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L-arginine, citrulline and pyrimidine derivatives including orotic acid, uridine, uridine 5'-monophosphate (UMP), cytidine and cytidine 5&#x2032;-monophosphate (CMP) are produced using a bacterium belonging to the genusharboring a mutant carbamoylphosphate synthetase in which the amino acid sequence corresponding to positions from 947 to 951 in a wild type carbamoylphosphate synthetase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 9, and feedback inhibition by uridine 5&#x2032;-monophosphate in the bacterium is desensitized.

Mutant carbamoylphosphate synthetase and method for producing compounds derived from carbamoylphosphate

L-arginine is produced using a bacterium belonging to the genusharboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.

Arginine can be efficiently produced by cultivatingwhich has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate arginine in the medium, and collecting arginine from the medium.

L-arginine producing Escherichia coli and method of producing L-arginine

L-arginine is produced using a bacterium belonging to the genus Escherichia harboring a mutant N-acetylglutamate synthase in which the amino acid sequence corresponding to positions from 15 to 19 in a wild type N-acetylglutamate synthase is replaced with any one of amino acid sequences of SEQ ID NOS: 1 to 4, and feedback inhibition by L-arginine is desensitized.

Mutant N-acetylglutamate synthase and method for L-arginine production

A method for producing shikimic acid, comprising the steps of cultivating a bacterium belonging to the genus Bacillus which is deficient in shikimate kinase activity and has shikimic acid productivity, or a bacterium belonging to the genus Bacillus which is deficient in 5-enolpyruvylshikimate-3-phosphate synthase activity and has shikimic acid productivity, in an medium, producing and accumulating shikimic acid in the medium, and collecting shikimic acid from the medium.

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Moscow, Russia

Tatyana Abramovna Yampolskaya