Chugai Seiyaku Kabushiki Kaisha

Tatuo Kujirai

Yoshimitsu Iida

Toshichika Ogasawara

Atsuko Yoshizawa

A prolonged-action multiple-layer tablet having an increased rate of dissolution of the active ingredient from a given point of time onward is disclosed. The tablet comprises layer A made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 .mu.m or less and which is solid at ordinary temperatures, a disintegrator and a binder, and layer B made of an intimate mixture of a water-insoluble wax that has an average particle size of 10 .mu.m or less and which is solid at ordinary temperatures, a disintegrator, a binder and the active ingredient. In the tablet, a quick-release layer containing the active ingredient may be formed on either layer A or B.

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Saitama, Japan

Tatuo Kujirai