Otsuka Pharmaceutical Company, Limited

Tatsuyoshi Tanaka

Hiroshi Yamashita

Nobuaki Ito

Shin Miyamura

Kunio Oshima

Hideaki Kuroda

Satoshi Shimizu

Haruka Takahashi

Jun Matsubara

Yasuo Oshiro

Kazuyuki Nakagawa

Takao Nishi

Shigeharu Tamada

Kazuyoshi Nagami

Tetsuro Kikuchi

Shuji Teramoto

Katsura Tottori

Yohji Sakurai

Shinichi Taira

Yoji Sakurai

Seiji Sato

Kazumi Kondo

Takeshi Kuroda

Tae Fukushima

Motohiro Itotani

Yoshiyasu Fukuyama

Keiichi Kuwahara

Shigeki Fujisawa

Osamu Hongoh

Nobutaka Fujisawa

Hiroshi Okazaki

Takashi Hasegawa

Yutaka Wada

Keiko Takasu

The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

Piperazine-substituted benzothiophenes for treatment of mental disorders

The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety. 

A heterocyclic compound or a salt thereof represented by the formula (1): where Rrepresents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and Rrepresents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety. 

Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders

Fluorenone derivatives, process for preparing the same and central or

Cyclic amide derivatives

Disclosed is carbostyril derivatives of the general formula ##STR1## wherein R.sup.1 is a halogen, a hydroxyl, lower alkoxy, lower alkyl, lower alkenyloxy, amino, lower-alkanoyl amino or lower alkylthio group, R.sup.2 is a phenyl group which may optionally have one or two substituents, A is a lower alkylene group, and n is an integer of 1 or 2 and wherein the carbon-carbon bond between the positions 3 and 4 of the carbostyril skeleton may be a single bond or a double bond, and salts thereof, and pharmaceutical compositions containing the same for use as a disturbance-of-consciousness improving agent, central nervous system stimulant or sigma receptor agonist.

Carbostyril derivatives and pharmaceutical compositions containing the

The present invention provides a disturbance-of-consciousness improving agent which is a highly effective and quick remedy and which can be administered orally. The disturbance-of-consciousness improving agent of the invention contains a sigma receptor agonist compound as an active ingredient.

Disturbance-of-consciousness improving agent

Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phosphodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

Dihydropyridine derivatives and process for preparing the same

There is disclosed a biphenyl derivative of the formula (B): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.c are as defined or its salt, a composition for nerve cell degeneration repairing or protecting agent containing a phenyl derivative selected from compounds (1) to (4) and (B) as defined, and a process for preparing a phenyl derivative contained in the composition.

Biphenyl derivative composition for nerve cell degeneration repairing or

Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

Novel dihydropyridine derivatives

Growing community of inventors

Tokushima, Japan

Tatsuyoshi Tanaka