Showa Corporation

Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Tatsuya Takahashi

Tetsuya Tamura

Hitoshi Kawai

Takao Mizumoto

Masao Shimasaki

Atushi Kajiyama

Yosuke Murakami

Tadashi Hachisuka

Kojiro Yoshida

Kimitoshi Sato

Masakazu Kuwahara

Yuji Ohuchi

Takatoshi Ohmi

A suspension apparatus includes: a cylindrical outer tube; an inner tube a piston rod of which one end portion retains a piston; and a partition wall member that is mounted to an upper end portion of the inner tube to define an upper end portion of an annular oil chamber, that has a bowl portion, and that divides a space inside the inner tube into an inner space and an outer space of the bowl portion, in which the partition wall member divides the outer space into a gap space and a space other than the gap space, a through-hole is formed in the partition wall member, and at least one of the partition wall member and the inner tube is provided with a communication path through which an upper portion of the annular oil chamber communicates with the gap space.

Suspension apparatus

An object of the present invention is to ensure that, during adjustment of a spring load by an adjuster, total fully-stretched lengths of an outer tube and an inner tube remain unchanged and the adjuster is prevented from protruding from an upper surface of a cap. In a hydraulic shock absorber, a spring load adjusting deviceis configured such that an adjusteris provided at an upper end portion of a vehicle body side tube, a push rodthat is moved up and down by the adjusteris penetrated into a hollow portion of a hollow rod, a suspension springis pressurized by the push rodthat protrudes from the hollow portion of the hollow rodto the inside of a wheel side tube, and the spring load of the suspension springcan be adjusted by the up-and-down motion of the push rodcaused by the adjuster

Hydraulic shock absorber

The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50 to approximately 250 &#x3bc;m and an apparent specific gravity of approximately 0.5 to approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and a saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier to a high concentration in terms of solid concentration in a solvent and spray drying this liquid and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising the particles.

Quick disintegrating tablet in buccal cavity and manufacturing method thereof

The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50&tilde;approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5&tilde;approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier (preferably containing water-insoluble polymer, particularly at least aqueous ethyl cellulose suspension (preferably containing plasticizer)) to a high concentration in terms of solid concentration in a solvent that is pharmaceutically acceptable and then spray drying this liquid using a rotating disk-type spray dryer, with the disk operating at low speed, and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising said particles.

Growing community of inventors

Shizuoka, Japan

Tatsuya Takahashi