Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Tatsuya Ito

Kiminori Tomimatsu

Tomomi Ikemoto

Hiroyuki Odaka

Yu Momose

Hiroyuki Kimura

Nobuyuki Takakura

Tsuyoshi Maekawa

Yasuhiro Sawai

Hirohiko Nishiyama

Yasushi Isogami

An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula wherein Ris an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is &#x2014;(CH)-Z-(n is an integer of 1 to 8 and Zis an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and Ris &#x2014;OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.

Alkanoic acid derivatives process for their production and use thereof

A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula:{wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; Rrepresents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then &#x2014;X&#x2014;CH-Z is not &#x2014;X&#x2014;X&#x2014;CH, -Z (wherein Xrepresents sulfur or optionally substituted nitrogen and Xrepresents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof:(wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.

Process for producing cyclic compound

A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula:{wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; Rrepresents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then &#x2014;X&#x2014;CH&#x2014;Z is not &#x2014;X&#x2014;X&#x2014;CH&#x2014;Z (wherein Xrepresents sulfur or optionally substituted nitrogen and Xrepresents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof:(wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.

Method for producing 1-substituted-1,2,3-triazole derivative

Processes for the preparation of 2,3-dihydrothiepine derivatives

Growing community of inventors

Kashiba, Japan

Tatsuya Ito