Mitsubishi Tanabe Pharma Corporation

Toyota Jidosha Kabushiki Kaisha

Tatsuya Ibuki

Maiko Hamada

Ryuta Yamazaki

Yasuki Niwa

Kiyomi Ohba

Tetsuji Matsudaira

Minoru Tanaka

Yoshihiro Sakayanagi

Yuko Ishida

Mitsuji Sampei

Ryunosuke Watanabe

Hiroto Yoshioka

Yuichi Sawaguchi

Hideto Maruyama

Shiki Matsuki

Provided is a compound or a pharmaceutically acceptable salt thereof which is superior in an action inducing degradation of BRD4 protein and useful as a therapeutic agent for cancer. A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the DESCRIPTION.

Sulfonamide or sulfinamide compound having effect of inducing BRD4 protein degradation and pharmaceutical use thereof

Provided are a compound superior in a cytotoxic action on cancer cells, an action inducing degradation of BET protein in cancer cells, and an inhibitory action on the binding of BET protein and acetylated histone, and useful as an anticancer agent, a BET protein degradation inducer or a BET protein inhibitor. A compound represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Amide compound having bet proteolysis-inducing action and medicinal application thereof

A control device of a vehicle comprises a vehicle control partconfigured to use a probability distribution of at least one predetermined parameter to calculate an expected value of each of at least one evaluation value and control the vehiclebased on the expected value.

Control device of vehicle

Growing community of inventors

Tokyo, Japan

Tatsuya Ibuki