Wakunaga Pharmaceutical Co., Ltd.

Tatsuya Hirano

Akira Yazaki

Satoshi Inoue

Yasuhiro Kuramoto

Kenji Itoh

Kouji Nishimura

Tomohiko Kinoshita

Yohei Kawakubo

Mai Arai

Asuka Sakurai

Masayuki Sato

Daichi Kazamori

Junpei Yamashita

Ayuka Sasaki

Tomonori Yamaguchi

Rumiko Shimabara

Taichi Ueshima

It is intended to provide a novel compound having high antitumor activity and low toxicity to normal cells. The present invention provides a pyridone carboxylic acid derivative represented by the following formula (1) or a salt thereof wherein Rrepresents a hydrogen atom, a halogen atom or the like; Rrepresents a hydrogen atom, a halogen atom or the like; Rto Reach represent a hydrogen atom or the like; Rrepresents a hydrogen atom or the like; Rrepresents a hydrogen atom, a halogen atom, the following formula (a) (wherein Rand Reach represent a hydrogen atom, a hydroxy group, an optionally substituted lower alkyl group or the like) or the like, or Rand Rtogether represent &#x2550;N&#x2014;OR(wherein Rrepresents a hydrogen atom, an optionally substituted lower alkyl group, or an aralkyl group), or Rand Rform an optionally substituted 4- to 6-membered saturated hetero ring together with the adjacent carbon atom, or the like; Rrepresents a hydrogen atom or the like; X represents a nitrogen atom or the like; and Y represents a nitrogen atom or the like. 

Pyridone carboxylic acid derivative or salt thereof

A pyridonecarboxylic acid derivative or a salt thereof is represented by Formula (1), where Ris hydrogen, a halogen atom, a lower alkyl group, or an amino group; Ris &#x2014;NH&#x2014;R, where Ris hydrogen, a lower alkyl group, an amino lower alkyl group, or the like; &#x2014;O&#x2014;R, where Ris hydrogen, a lower alkyl group, or the like; &#x2014;(CH)&#x2014;R, where Ris an amino group or the like, m is 1, 2, 3 or 4; or a cyclic amino group of Formula (2), where Y represents NH or C&#x2014;RR, where Rand Rare each independently hydrogen, a lower alkyl group, an amino group, a lower alkyl amino group, or the like; n and p are 1 or 2; Ris hydrogen, a halogen atom, a lower alkyl group, or the like; Ris hydrogen or a carboxyl group-protecting group; and Ris hydrogen or a hydroxyl group-protecting group. 

Pyridonecarboxylic acid derivative or salt thereof

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Akitakata, Japan

Tatsuya Hirano