Seikagaku Kogyo Kabushiki Kaisha

Seikagaku Corporation

Tatsushi Muta

Toshio Oda

Sadaaki Iwanaga

Noriaki Seki

Hiroshi Tamura

Masayuki Tanaka

A (1&#x2192;3)-&#x3b2;-D-glucan binding protein, a fluorescence-labeled (1&#x2192;3)-&#x3b2;-D-glucan binding domain protein, a (1&#x2192;3)-&#x3b2;-D-glucan measuring agent comprising the same, a method for measuring (1&#x2192;3)-&#x3b2;-D-glucan using the same, and a (1&#x2192;3)-&#x3b2;-D-glucan assay kit comprising the same.

(1&#x2192;3)-&#x3b2;-D-glucan binding domain protein, measuring method using the substance and assay kit

This invention relates to a DNA shown by SEQ ID No. 1 and an amino acid sequence coded by said DNA. This invention also relates to a DNA and an amino acid sequence of subunit a of (1.fwdarw.3)-.beta.-glucan sensitive factor derived from amebocytes of horseshoe crab and have potent affinity to (1.fwdarw.3)-.beta.-D-glucan in cell walls of fungi. Therefore, the invention is useful for the diagnosis of fungal diseases and as antimicrobial or eradicating agent of fungi in combination with an antifungal agent.

DNA encoding horseshoe crab amebocyte lysate factor G subunit A

Horseshoe crab amebocyte lysate factor G subunit A

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Fukuoka, Japan

Tatsushi Muta