Sanwa Kagaku Kenkyusho Co., Ltd.

Kabushiki Kaisha Asano Kenkyusho

Tatsushi Maeda

Makoto Sato

Toshihiro Takai

Toshiyuki Kouzaki

Shigeaki Yoshina

Takashi Kikkawa

Kenichi Mizoguchi

Akio Yoshikoshi

Masanao Nakoshi

Yoko Ishihara

A thermoforming apparatus includes a female die and a movable plug for thermoforming a softened thermoplastic resin sheet. The female die includes a rim forming recess in the shape of a bowl-shaped recess, communicating with a bottom opening and forming a bottom wall of the bowl, an outer wall, a bottom wall and an inner wall of a rim of the bottom, and a bottom plate movable forward and backward relative to the rim forming recess. The softened thermoplastic resin sheet is thrust by the plug while the bottom plate is held at a first stop position. The thermoplastic resin sheet is brought into contact with an inner circumferential surface of the bowl-shaped recess and then the bottom plate is moved to a second stop position so that a rim is formed.

Thermoforming process

A pharmaceutical composition is disclosed comprising a fat emulsion containing microspheres and having its electric charge adjusted to a negative value and a biologically active substance selected from the group consisting of a basic peptide and a basic protein, which biologically active substance is adsorbed to the microspheres in the fat emulsion. An acidic phospholipid, a fatty acid, a bilic acid and a salt of such substances is preferred as an agent for adjusting the electric charge of the fat emulsion. Motilin derivatives, vasoactive intestinal polypeptide derivatives and calcitonin are preferred biologically active substances.

Pharmaceutical composition containing biologically active peptide or

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Aichi-ken, Japan

Tatsushi Maeda