Daiichi Pharmaceutical Co., Ltd.

Kuraray Co., Ltd.

Daiichi Sankyo Company, Limited

Tatsuru Saito

Toshifumi Akiba

Naoki Ohta

Tutomu Ebata

Sadahiro Shimizu

Keiichi Hirai

Toshiaki Tojo

Yuichiro Tani

Naoshi Nakagawa

Katsuji Ujita

Tatsuhiko Hayashibara

Makoto Muto

Kenichi Koyakumaru

Keiji Nakayama

Toshiaki Jouno

Shingo Ueyama

A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.

Process for producing cyclopropane monoacetal derivative and intermediate therefor

A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation. 

Processes for preparation of bicyclic compounds and intermediates therefor

This invention relates to methods for the efficient production of quinolonecarboxylic acid based synthetic antibacterial agents which are expected for applications such as excellent medicaments and agricultural chemicals and to intermediate compounds to be used therein. According to the present invention, an amine substituent as the 7-position substituent of the quinolonecarboxylic acid derivative can be efficiently introduced.

Process for producing quinolonecarboxylic acids and intermediates thereof

Production process of cyclic compound

This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of formula (I), and also to provide a novel synthetic process for the inexpensive, short-step and industrially advantageous production thereof. ##STR1##

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Edogawa-ku, Japan

Tatsuru Saito