Matsushita Electric Industrial Co., Ltd.

Panasonic Corporation

Panasonic Intellectual Property Management Co., Ltd.

Imec Vzw

Tatsurou Kawamura

Akihito Kamei

Nobuo Sonoda

Masahiko Shioi

Masaru Minamiguchi

Yasuaki Okumura

Hisashi Minemoto

Katsuya Wakita

Hiroshi Onishi

Tetsuji Kawakami

Yusuke Ozaki

Keiko Yugawa

Nobuyuki Shigetoh

Jinsei Miyazaki

Fumihisa Kitawaki

Atsushi Matsubara

Liesbet Lagae

Yoshiki Sasaki

Hiroshi Nakayama

Yukari Nishiyama

Tim Stakenborg

Hiroto Yanagawa

Takahiro Aoki

Nobuyuki Shigetou

Noriko Shimba

Ben Jones

Shuji Sato

A detection apparatus includes: a substrate; a metal nanostructure on a surface of the substrate and on which immobilized antibodies having a property of binding with a detection object substance are immobilized, the metal microstructure generating a surface plasmon by being irradiated with excitation light; an introducer that introduces labeled antibodies having a property of binding with the detection object substance and labeled with a fluorescent material, and a test solution containing the detection object substance into the metal nanostructure; a light source that irradiates the metal nanostructure with the excitation light from the back surface side of the substrate; and a photodetector that detects the detection object substance based on fluorescence generated from the fluorescent material in response to irradiation of the excitation light. The metal nanostructure includes a light transmissive portion that transmits, to the surface side of the substrate, the excitation light emitted from the back surface side thereof.

Detection apparatus, detection substrate, and detection method

A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.

Pathogen detection apparatus and pathogen detection method

A micro analysis chip comprises an inlet and a fluid flow path communicating thereto. The fluid flow path comprises a first flow path, a second flow path, and a third flow path arranged continuously along a longitudinal direction of the fluid flow path. An antibody is bound on at least one peripheral surface selected from the group consisting of peripheral surfaces of the second and third flow paths. A cross-sectional area of the third flow path is constant or increased monotonically along a direction X from the second flow path toward the third flow path. A cross-sectional area of the second flow path is increased monotonically along the direction X from the one end to the other end of the second flow path. A cross-sectional area of the first flow path is larger than a cross-sectional area at the one end of the second flow path.

Micro analysis chip and fabrication method thereof

The present invention provides a method for detecting an analyte with high sensitivity. In the present method, a solution is supplied onto a substrate comprising a first electrode and a second electrode. Then, an alternating voltage is applied between the first electrode and the second electrode to aggregate, onto the surface between the first electrode and the second electrode by dielectrophoresis, bioparticles and dielectric particles contained in the solution. The aggregated bioparticles are broken to release the analyte contained in the bioparticles. The released analyte is bound to a first antibody and a second antibody to cause the dielectric particles to be immobilized onto the substrate through formation of a sandwich structure composed of the first antibody, the analyte, and the second antibody. Finally, the analyte is detected through the fluorescent substance contained in the immobilized dielectric particles.

Analyte detection by dielectrophoresis

A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.

Sensor embedding device and sensor embedding system

An exemplary sensor chip includes a substrate, a metal pattern formed on a side of the substrate that is irradiated with excitation light, and a first substance and a second substance provided near the metal pattern. A first intensity Xa of the first surface-enhanced Raman-scattered light from the first substance and a second intensity Xb of the second surface-enhanced Raman-scattered light from the second substance are detected. An intensity ratio Xc, as obtained by dividing the second intensity Xb with the first intensity Xa, is calculated.

Method and detection system for detecting an analyte

An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.

Method and apparatus for measuring concentration of test substance in organism

An exemplary sensor chip includes a substrate, a metal pattern, a proximate substance, and a light shielding layer. The metal pattern is on the substrate. The proximate substance is on or near the metal pattern. The light shielding layer is provided on the substrate so as to cover the metal pattern and the proximate substance. The light shielding layer is a layer that blocks the excitation light from going into the proximate substance, and is made of a substance which becomes degraded inside a subject.

Sensor chip, detection method, and detection apparatus

A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.

Method for measuring concentration of antigen contained in test solution

One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.

Method for measuring a concentration of a biogenic substance contained in a living body

The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation:()=Am &#xb7;sin(&#x3c9;)+, where(): received signal, Am: amplitude,: time,: a constant number, and &#x3c9;: angular speed.

One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.

In a vital data utilization system (), measurement systems () include a measurement unit () measuring the vital data of subjects, a clock unit detecting each measurement time at which vital data is measured and a communication unit () sending the vital data including measurement time to a server (). Further, a server () includes a communication unit () receiving pieces of vital data from measurement systems (), a vital data storage unit () in which vital data is stored, a value-added information making unit () making the value-added information indicating the geographical distribution of the vital data or the changes over time of the geographical distributions of the vital data based on vital data stored in the vital data storage unit () and a communication unit () providing the made value-added information to the measurement systems () and the PCs of service destinations.

Biological information utilization system, biological information utilization method, program, and recording medium

A specific binding analysis method capable of controlling the amount of specific binding to freely setting the sensitivity, concentration range and the like in an analysis, and a device used therefore are provided. In order to optimize the amount of specific binding, the specific binding analysis method and the device used therefor restrain the amount and velocity of a sample passing, by capillarity, through a detection zone, by controlling the dimensions, ventilation resistance, hydrophilicity and the like in the portion of the device where the sample passes through.

Method for analyzing an analyte qualitatively and quantitatively

The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.

Growing community of inventors

Kyoto, Japan

Tatsurou Kawamura