Shin Nippon Biomedical Laboratories, Ltd.

Other

Bioactis Limited

Tatsuo Tsutsui

Akira Yanagawa

Shunji Haruta

Ryoichi Nagata

[Subject] A test substance application system for animal experiment capable of administering a required amount of a test substance uniformly and reliably from a nose or a mouth into a nasal cavity or into a lung of an experimental animal is provided. [Means for Solution] The system includes a respiration monitoring devicethat monitors a respiration state of an experimental animal detected by a respiration pick-up deviceto thereby measure a timing upon switching from an expiratory phase to an inhalatory phase and outputs a trigger signal T at that timing, and an application devicethat sprays a predetermined amount of a test substance into a nasal cavity or an oral cavity of the experimental animal when the trigger signal T is outputted from the device

Test substance administration system for animal experiment

Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices. Formulations and methods of manufacture are provided for dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations.

Intranasal delivery devices

Improvement for the device to deliver the powdery medicine into nasal cavities in which a capsule setting/detaching partis built drawably in the capsule housing/holding partand cutting bladesA,B are built in both axial ends of the capsule setting/detaching partof the capsule housing/holding partfor cutting both axial ends of the capsule thereby perforating the capsule. A medicine capturing/collecting partand a one-way valveare built in a lower portion of the capsule housing/holding partand a pumphaving an air inlet valveis built in the air flow inlet side thereof. A medicine delivery partis built in the air exit of the capsule housing/holding parta nozzleis installed and medicine in the capsule can be dosed to the nasal cavities of the user by pressing the pump

Powder medicine applicator for nasal cavity

Formulations and methods of manufacture are provided for granisetron dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations. Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices.

Intranasal granisetron and nasal applicator

A peroral powder delivery device having a capsule holder for loading the capsule into a body is attached so as to be capable of advancing into and retracting from the inside of the body, the body has a cutter blade to make holes on both ends of the capsule as it advances into the body being held by the capsule holder, first and second air passageways having connection ports in communication with the holes in the capsule loaded in the body, the first air passageway has an inhaling port for inhaling the peroral powder in the capsule and the second air passageway has a suction valve that opens by the inhaling force from an inhaling port introduce air into the capsule.

Peroral powder delivery device

A device that delivers a powdery medicine for a nasal cavity includes positioning guides that cause a capsule to slide as far as a predetermined position and are provided on the side of cutters to make holes on both ends of the capsule provided between the connection port on the side of a nozzle that sprays the powdery medicine into the nasal cavity. The device further includes a connection port on the side of a pump that supplies spray air to the nozzle in order to make the size of the holes made on both ends of the capsule constant, wherein a distance between the connection ports is made shorter than a distance between blade tips of the cutters.

Device to deliver a powdery medicine into nasal cavity

In a device to deliver a powdery medicine into a nasal cavity, one-way valveis built in an air flow passageof a capsule housing/holding part, the one-way valveis controlled for the opening pressure by a springand opens by a pressure of air from the pump, the one-way valve enddoes not interfere the setting/detaching operation of the capsule setting/detaching partand the capsule K when the one-way valveis opened and intrudes as far as the inside of the capsule to disperse the medicine in the capsule K when the one-way valveis opened by pressing of the pumpupon dosing thereby capable of reliably dosing at a adequate dose also including the medicine falling as far as the one-way valveto the nasal cavity of the user.

Powder chemical feeding device for nasal cavity

A gas spray valve permits easy recharging of gas containers after use. The gas spray valve is of considerable strength and rigidity and can be manufactured in a less costly manner. One of the openings of a gas conduit of a valve pin is positioned so that, when the valve pin is in the raised position, the opening is positioned above a second seal ring and, when the valve pin is pushed into a first stop position, the opening is positioned below the second seal ring. When the valve pin is in the raised position, a bottom end of the valve pin is positioned above a first seal ring, and as the result, the interior of a gas container is connected with a metering chamber. When the valve pin is pushed into a second stop position, the opening of the gas conduit is positioned below the first seal ring so that the interior of the gas container communicates with the gas conduit. This permits recharging of the gas container with the gas.

Gas injection valve and filling jig used for filling gas

A gas spray valve permits easy recharging of gas containers after use. The gas spray valve is of considerable strength and rigidity and can be manufactured in a less costly manner. One of the openings of a gas conduit of a valve pin is positioned so that, when the pin is in the raised position, the opening is positioned above a second seal ring and, when the valve pin is pushed into a first stop position, the opening is positioned below the second seal ring. A gas supply passage is provided that connects the interior of a gas container with a metering chamber on the inside of a first seal ring only when the valve pin is in the raised position. When the valve pin is in the raised position. When the valve pin is pushed into a second stop position, the opening of the gas conduit is positioned below the first seal ring so that the interior of the gas container communicates with the gas conduit. This permits recharging of the gas container with the gas.

A gas spray valve permits easy recharging of gas containers after use. The gas spray valve is of considerable strength and rigidity and can be manufactured in a less costly manner. One of the openings of a gas conduit of a valve pin is positioned so that, when the pin is in the raised position, the opening is positioned above a second seal ring and, when the valve pin is pushed into a first and second stop position, the opening is positioned below the second seal ring. A gas supply passage is provided that connects the interior of a gas container with a metering chamber on the inside of a first seal ring only when the valve pin is in the raised position. When the valve pin is pushed into a second stop position, the portion with the smaller diameter of the valve pin is pushed down below the first seal ring so that the interior of the gas container communicates with the metering chamber and the gas conduit. This permits recharging of the gas container with the gas.

Gas injection valve, and injection jig used for gas injection

A gas ejection valve includes a valve casing including first and second blocks that cooperate to define a holder groove and have a first mating face formed with an annular space, an inner peripheral seal ring disposed on the inner periphery of the valve casing to be in close contact with the outer periphery of a valve pin and being received in the holder groove, and an auxiliary seal ring received in the annular space for preventing communication between the inside of the gas container and the holder groove.

Pressure relief valve for an inhalator

A valve includes a valve case secured to a container that stores a pressurized fluid, and a valve pin moveable relative to the valve case and defining a fluid path in cooperation with the valve case. A seal separates the fluid path into an upstream portion communicating with inside of the container and a downstream portion communicating with outside of the container. The valve pin has a main passage always communicating with outside of the container, and a bypass passage. A valve pin adjuster, responsive to change in pressure acting on the valve pin within the container, shifts the valve pin between a first position where fluid communication between the main passage and the upstream portion of the fluid path is blocked to prevent the pressurized fluid from being discharged from the container, and a second position where fluid communication between the upstream and downstream portions of the fluid path is established through the bypass passage to allow the flow of the pressurized fluid from the container.

A valve and an inhalator with the valve are disclosed. A valve case is secured to a container storing pressurized fluid. A valve pin is moveably mounted to the valve case. First and second seals are arranged in a spaced relation in an axial direction of the valve pin. The first seal is mounted onto a piston portion of the valve pin that is received in the valve case and exposed to the pressurized fluid. The valve pin is formed with a fluid passage having an outlet communicating with the outside of the container and an inlet communicating with a space between the piston portion and the valve case and arranged between the seals in a spaced relation. The valve pin takes a first position where the first seal cooperates with the valve case to block fluid communication between the inside and the outside of the container through the space and the fluid passage and a second position where the first seal cooperates with the valve case to establish the fluid communication between the inside and the outside of the container therethrough.

Inhaler and valve therefor

A gas injection valve comprises a valve casing fitted to a gas bottle, a valve pin slidably received in the valve casing, first and second seal rings fitted to the inner peripheral wall of the valve casing, and a fixed-quantity chamber defined between the first and second seal rings for capturing therein a fixed amount of gas before injection. The valve pin has a gas passage bore for intercommunicating a first port formed in the upper face of the tip of the valve pin and a second port formed in the outer peripheral wall of the valve pin. The second port is located to open into the substantially cylindrical hollow of the casing above the second seal ring with the valve pin kept in a lifted-up position and to open into the fixed-quantity chamber below the second seal ring during one-step pushing action and two-step pushing action of the valve pin. A first bypass portion is formed in the valve pin for intercommunicating the interior of the gas bottle and the fixed-quantity chamber through a partial space of the substantially cylindrical hollow near the first seal ring in the lifted-up position of the valve pin. A second bypass portion is formed in the valve pin for intercommunicating the interior of the gas bottle and the fixed-quantity chamber through the partial space of the substantially cylindrical hollow near the first seal ring only during the two-step pushing action.

Growing community of inventors

Kanagawa, Japan

Tatsuo Tsutsui