Chugai Seiyaku Kabushiki Kaisha

Other

Kuraray Co., Ltd.

Kyowa Hakko Kogyo Co., Ltd.

Tatsuo Suda

Sachiko Yamada

Etsuko Abe

Masayuki Ishikawa

Hiromichi Suzuki

Tadashi Yoshida

Satoshi Sasaki

Hideharu Anazawa

Masao Tanihara

Kunio Konno

Seiji Sugimoto

Chikara Kaneko

Hiroaki Takayama

Akiko Sugimoto

Yoshihei Hirasawa

Tadao Aoki

Takao Saruta

Shu Wakino

Yuzuru Ishimura

Toshimasa Shinki

Hiroko Shimada

Chie Fujiwara

Sachio Takahashi

Keiko Nakayama

Toshiaki Monkawa

Matsuhiko Hayashi

25-hydroxyvitamin D3-1&agr;-hydroxylase and DNA encoding the hydroxylase

Peptides having high binding activity for human interleukin-1 and represented by the following formula

Peptide or its salts

There are disclosed 6,19-epidioxyvitamin D.sub.3 derivatives which are represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom or a hydroxyl group; when R.sub.1 is a hydrogen atom, R.sub.2 represents a hydroxyl group and R.sub.3 is a hydrogen atom or a hydroxyl group; when both R.sub.1 and R.sub.2 represent a hydroxyl group, R.sub.3 is a hydrogen atom or a hydroxyl group; and when R.sub.1 is a hydroxyl group and R.sub.2 is a hydrogen atom, R.sub.3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.

Novel vitamin D.sub.3 derivatives and process for producing the same

A method of leukemia or leukemoid disease treatment by administration of a vitamin D derivative with a hydroxyl group at 1.alpha.-position is disclosed. It is believed that the vitamin D derivative with a hydroxyl group at 1.alpha.-position is capable of treating cancer through redifferentiation of cancer cells and that this capability is inherent in vitamin D derivatives with a hydroxyl group at 1.alpha.-position.

Method of treating leukemia or leukemoid diseases

1.alpha.,2.alpha.-Dihydroxycholecaliciferol having improved vitamin D activities and a process for preparing the same are disclosed.

1.alpha., 2.alpha.-Dihydroxycholecalciferol and process for preparing

Growing community of inventors

Tachikawa, Japan

Tatsuo Suda