Hoffmann-La Roche Inc.

Basilea Pharmaceutica Ag

Tatsuo Ohtsuka

Kenichi Kawasaki

Nobuo Shimma

Kazuteru Yokose

Miyako Masubuchi

Masahiro Aoki

Kiyoaki Sakata

Pingli Liu

Toshihiko Fujii

Toru Okuda

Yuhko Aoki

Hirosato Ebiike

Miyako Kamata

Shinji Tsujii

Tsunehisa Aoyama

Akiko Sakai

Mikayo Kamata

This invention is concerned with novel polycyclic compounds of formula [I],wherein ring A, ring B, R, R, R, R, R, R, X, Y, R, R, R, R, R, R', ring A&#x2032;, ring B&#x2032; and X&#x2032; are as defined hereinabove as well as pharmaceutically acceptable salts thereof. The compounds have anti-tumor activity and are useful for the treatment of cell proliferative disorders.

Polycyclic compounds exhibiting anti-tumor activities

Polycyclic compounds

Bicyclic compounds

The compound of formula, ##STR1## is obtained from cultures of Chaetosphaeronema hispidulum. The compound is an inhibitor of phospholipase C.

Hispidospermidin

The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a carboxy-protecting radical; R.sup.2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen atom; R.sup.3 and R.sup.4 independently are a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical or a substituted or unsubstituted amino radical; X is a halogen atom; and R.sup.5 and R.sup.6 are independently a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical, a lower alkoxy radical or a substituted or unsubstituted amino radical; or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, may form a 5 to 7 membered heterocyclic ring which may be substituted with one or more substituents at the carbon atom(s), and the heterocyclic ring may further contain --NR.sup.7 --, --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.7 --CO--, and also R.sup.7 is a hydrogen atom, a lower alkenyl radical, a lower alkyl or aralkyl radical which may be substituted, or a radical represented by the formula

Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives

Pyrido(3,2,1-IJ)-1,3,4 benzoxadiazine derivatives

Growing community of inventors

Kamakura, Japan

Tatsuo Ohtsuka