Mitsui Toatsu Chemicals, Incorporated

Tatsuo Kaiho

Nobuyuki Fukazawa

Kengo Otsuka

Hiroyuki Yamashita

Seitaro Kajiya

Masahiko Maruyama

Fumiaki Ikeda

Makoto Hirayama

Yukio Miyama

Shimada Shizuo

Catechol derivatives which produce nerve growth factor in particular tissues of the brain are disclosed. These derivatives provide preventive and therapeutic effects for regressive disorders of the central nervous system including senile dementia of the Alzheimer type.

Catechol derivatives and pharmaceutical preparations containing same

This invention relates to a novel process for preparing 4-acetyl-1-methyl-7-pyridyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone characterized by condensing 2-acetyl-4-pyridyl cyclohexanone with acetoacetamide. This compound is useful as pharmaceuticals, particularly cardiotonics.

Process for preparing 4-acetyl isoquinolinone compounds

The isoquinoline derivatives represented by the following general formula (I) are useful as cardiotonics having high cardiotonic activity and low toxicity: ##STR1## where R.sub.1 represents a lower C.sub.1 -C.sub.4 alkyl group or cyclopropyl group,

Isoquinoline derivatives

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Kanagawa, Japan

Tatsuo Kaiho