Harbor Branch Oceanographic Institution, Inc.

Kirin Beer Kabushiki Kaisha

Pharma Mar, S.a.

Instituto Biomar, S.a.

Tatsuo Higa

Ryuichi Sakai

Kenneth M Snader

Shinichi Sakemi

Dolores Garcia Gravalos

Yasuhiko Koezuka

Sue S Cross

May S Lui

Takenori Natori

Teruyuki Sakai

Kazuhiro Motoki

Jose Luis Fernandez Puentes

Paul J Scheuer

Koji Akimoto

Junichi Tanaka

Jun-Ichi Tanaka

Khanit Suwanoborirux

Toshio Ichiba

Masahiro Morita

Shigeo Kohmoto

Carsten Christophersen

G Bernardinelli

C W Jefford

Compounds of formula (I) wherein Ris selected from H, C(&#x2550;O)R', P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, or substituted or unsubstituted aryl; or Rtogether with Rforms a saturated or unsaturated heterocyclic ring; Rand Rare each, independently, selected from H, C(&#x2550;O)R&#x2032;, P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, or substituted or unsubstituted aryl; or one of Ror Rtogether with Rforms a saturated or unsaturated heterocyclic ring; or Rand Rtogether form a saturated or unsaturated heterocyclic ring; Ris selected from H, C(&#x2550;O)R&#x2032;, P(&#x2550;O)R&#x2032;R&#x2033;, S(&#x2550;O)R&#x2032;R&#x2033;, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-C, alkynyl, or substituted or unsubstituted aryl, wherein R&#x2032; is selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted and unsubstituted aryl; R&#x2033; is selected from the group consisting of H, OH, NO, NH, SH, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted and unsubstituted aryl; wherein X, XXon formula I are independently placed in any particular position of the chain and independently selected from H, OH, OR&#x2032;, SH, SR&#x2032;, SOR&#x2032;, SOR&#x2032;, NO, NH, NHR&#x2032;, N(R&#x2032;), NHC(O)R&#x2032;, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, wherein substituent groups defined by R&#x2032; are each independently selected from the group consisting of H, OH, OR&#x2032;, SH, SR&#x2032;, SOR&#x2032;, SOR&#x2032;, NO, NH, NHR&#x2032;, N(R&#x2032;), NHC(O)R&#x2032;, CN, halogen, &#x2550;O, C(&#x2550;O)H, C(&#x2550;O)CH, COH, COCH, substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaromatic; wherein x is 6 to 20; and wherein the dotted lined is one or several optional double bonds placed in any particular position of the side chain; or pharmaceutically acceptable salts thereof are useful as antitumor compounds and include compound IK-8-73-4 of structure (a) which was isolated from a spongesp.

Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity

Cytotoxic tris(oxazole)-containing macrolides

The present invention relates to the novel .alpha.-galactosylceramide represented by the formula (A): ##STR1## wherein R represents ##STR2## where R.sub.2 represents H or OH and X denotes an integer of 0-26, or R represents --(CH.sub.2).sub.7 CH.dbd.CH(CH.sub.2).sub.7 CH.sub.3 and R.sub.1 represents any one of the substituents defined by the following (a)-(e):

.alpha.galactosylceramide derivatives

Sphingoglycolipid compounds and therapeutic uses thereof

Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: ##STR1## in which R.sup.1 is H or lower alkyl; R.sup.2 is OH or CH.sub.3 ; R.sup.3 is OH or CH.sup.3, and R.sup.4 H or MPTA. The compounds have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.

Cytotoxic compounds

This invention relates to antitumor compositions, and a method for inhibiting, remitting or controlling the growth of tumors or tumor cells utilizing antitumor compositions. More particularly, the antitumor compositions comprise, as active ingredient, an antitumor effective amount of halogenated chamigrenes extracted and derived from red alga and sea hares which diet upon red alga.

Antitumor chamigrene derivatives and their methods of use

This invention relates to antiviral and antitumor compositions, a process for producing the compositions and a method for inhibiting viruses and tumors utilizing the compositions. More particularly, the compositions are cyclohexadienone derivatives which are derived from red alga Desmia hornemanni.

Antiviral and antitumor cyclohexadienone compositions

This invention relates to antiviral compositions, a process for producing the compositions and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are halogenated chamigrenes extracted from sea hares which diet upon red algae.

Anti-viral chamigrene derivatives

This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Amphimedon sp.

Antitumor alkaloids

This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge genus Haliclona.

This invention relates to antitumor alkaloid compositions, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are antitumor alkaloids which are derived from marine organisms, i.e., the marine sponge Xestospongia, sp.

This invention relates to antitumor cyclohexanone compositions and derivatives thereof, a process of producing the compositions and a method for inhibiting tumors utilizing the compositions. More particularly, the compositions are cyclohexanone and derivatives thereof which are derived from marine organisms, i.e., the acord worm, Ptychodera sp.

Antitumor cyclohexanone compositions and derivatives thereof

This invention relates to novel macrolide compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the compositions. More particularly, the novel macrolide compositions are organic misakinolide and misakinolide derivative compositions which are derived from marine sponges genus Theonella.

Misakinolide compositions and their derivatives

This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral Tubastrea aurea.

Antiviral guanidine derivatives compositions and their methods of use

This invention relates to novel compositions which are useful as antitumor, antiviral and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, viruses and fungi utilizing the composition. More particularly, the novel compositions are derived from marine sponge Theonella sp.

Growing community of inventors

Okinawa, Japan

Tatsuo Higa