Sankyo Company, Limited

Tatsuo Haneishi

Mutsuo Nakajima

Akio Torikata

Takao Okazaki

Mamoru Arai

Seigo Iwado

Masatoshi Inukai

Takeshi Kinoshita

Keiko Shimizu

Yoshiharu Sakaida

Ryuzou Enokita

Fujio Isono

Kohei Furuya

Katsuhiko Kawakubo

Ryuzo Enokita

Kiyoshi Koi

Toshiaki Katayama

Manbu Tohjigamori

Yo Takiguchi

Sadao Sato

Masaki Nakahara

Sadao Sata

Yasuhiro Itoh

The process for producing mureidomycin A, B, C or D or a salt thereof by cultivating Streptomyces flavidovirens SANK 60486, FERM BP-1347, in a culture medium therefor and isolating mureidomycin A, B, C or D or a salt thereof from the cultured broth.

Fermentation process for preparing antibiotics mureidomycins A, B, C and

A new compound, named Substance No. 51262, may be produced by cultivating a suitable microorganism of the genus Streptomyces, especially the new strain SANK 63584 (FERM BP-958). Said compound has herbicidal and growth retardant properties. Said compound has the following structural formula: ##STR1##

Process for the production of an imidazoledione compound by a strain of

New antibiotics of the mureidomycin group have the formula ##STR1## wherein X represents the group ##STR2## and wherein R represents hydrogen, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one substituent selected from halogen and alkyl groups having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flaviodovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). Alternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formula

Antibiotics of the mureidomycin group, their preparation, and their

Novel compounds, called mureidomycins A, B, C and D, may be prepared by cultivation of a suitable microorganism of the genus Streptomyces, especially Streptomyces flavidovirens SANK 60486 (FERM P-8636, FERM BP-1347). These represent a wholly new class of antibiotics, which are valuable in the treatment of infections caused by a variety of bacteria, notably of the genus Pseudomonas.

Antibiotics called 'mureidomycins A, B, C, and D' and their therapeutic

Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

Antibiotics called 'chloropolysporins B and C', a process for their

A novel compound names 'cornexistin' has the formula (I): ##STR1## and it and the corresponding ring-opened diacid and salts thereof have herbicidal and growth regulating effects. Cornexistin can be prepared by cultivation of a microorganism of the genus Paecilomyces, e.g. Paecilomyces variotii Bainier SANK 21086.

Herbicide, its preparation and use

Imidazoledione compounds useful as herbicides

Novel compounds, called chloropolysporins B and C, and salts thereof have antibiotic properties and would appear to be members of the class of glycopeptide antibiotics containing chlorine. They may be produced by cultivating a suitable strain of miroorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). They may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

Antibiotics called `chloropolysporins B and C`, a process for their

A novel compound named 'cornexistin' has the formula (I): ##STR1## and it and the corresponding ring-opened diacid and salts thereof have herbicidal and growth regulating effects. Cornexistin can be prepared by cultivation of a microorganism of the genus Paecilomyces, e.g. Paecilomyces variotii Bainier SANK 21086.

Anhydride herbicides

A novel compound, called chloropolysporin, has antibiotic properties and would appear to be a member of the class of glycopeptide antibiotics containing chlorine. It may be produced by cultivating a suitable strain of microorganism of the genus Micropolyspora, especially Micropolyspora sp. SANK 60983 (FERM BP-538). It may be combined with conventional pharmaceutically acceptable carriers or diluents for therapeutic use or incorporated into edible excipients, such as feed or water, for use as a growth-promoting agent, especially for farm animals.

Antibiotic called 'chloropolysporin', a process for its preparation, and

Macrolide antibiotics are derivatives of the compound Mycoplanecin and have the formula: ##STR1## (in which R represents a hydrogen atom or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group). The compound in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group can be prepared by reducing Mycoplanecin and the compound in which R represents a hydrogen atom can be prepared by the hydrolysis of Mycoplanecin or of the compound of formula (I) in which R represents an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group.

Macrolide antibiotic

Mycoplanecin derivatives of formula (I): ##STR1## [wherein: R represents a hydrogen atom, an N-(.alpha.-ketobutyryl)-N-methylvalyl group or an N-(.alpha.-hydroxybutyryl)-N-methylvalyl group;

Mycoplanecin derivatives and their preparation

A novel antibiotic substance, named 'Mycoplanecin', of presently unknown structural formula, is produced by cultivating a Mycoplanecin-producing microorganism of the genus Actinoplanes, especially the Actinoplanes nov. sp. Strain No. 41042, NRRL No. 11462.

Antibiotic substance

New antibiotic substances named substance No. 17927A.sub.2 and substance No. 17927A.sub.1 produced by cultivation of substances No. 17927A.sub.2 and No. 17927A.sub.1 -producing microorganisms belonging to the genus Streptomyces as well as pharmaceutically-acceptable salts thereof. They have broad antibacterial activities and also .beta.-lactamase inhibitory action so that they show synergistic actions with known penicillins and cephalosporins.

Growing community of inventors

Tokyo, Japan

Tatsuo Haneishi