Olympus Corporation

Olympus Optical Company, Ltd.

Japanese Foundation for Cancer Research

Japanese Foundation Fox Cancer Research

Tatsuki Yamada

Yamato Kanda

Makoto Kitamura

Yuichi Ishikawa

Takashi Yoneyama

Akihiro Kubota

Takashi Nagano

Mitsutaka Kimura

Kengo Takeuchi

Shuji Nakagawa

Kiyoshi Yuri

Futoshi Akiyama

Rie Horii

Zheng Li

A diagnosis support apparatus includes a processor including at least one piece of hardware. The processor identifies, based on physical information including one or more kinds of information capable of estimating a state of a diagnosis target organ of a subject, one abnormal symptom appearing in the diagnosis target organ, performs, as lesion extraction processing for extracting a lesion candidate region from an endoscopic image, different processing specialized for each abnormal symptom that appears in the diagnosis target organ, and performs the lesion extraction processing corresponding to the identified one abnormal symptom.

Control apparatus, diagnosis support method, and recording medium

Provided is a microscope system including: a stage on which a multi-dyed specimen is mounted; an objective lens for collecting light from the specimen mounted on the stage; a Z-axis movement section for relatively moving the stage and the objective lens in a direction along the optical axis L of the objective lens; an XY-axis movement section for moving the stage in a direction orthogonal to the optical axis L; an image acquisition unit for acquiring a color image by capturing the light collected by the objective lens; and a depth-extension processing unit for generating a depth-extended image by performing depth extension processing dye by dye on the basis of a plurality of the color images that are acquired by the image acquisition unit at different positions of the stage relative to the objective lens set with the Z-axis movement section.

Microscope system

A microscope system including an objective lens, a camera for capturing an image of light that comes from a specimen and that is collected by the objective lens, a stage for moving the specimen and the objective lens relative to each other in a direction perpendicular to an optical axis, a controller implementing a VS-image generation for generating a VS image by joining a plurality of microscope-image groups that are acquired while moving the objective lens and the specimen relative to each other, a correction-region search for searching for a correction region for acquiring a correction image, a correction-data generation for generating shading-correction data based on the correction image acquired for the searched-for correction region, and a shading correction for performing correction by using the generated shading-correction data.

A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that obtains dye amounts of the element identification dye and the molecule target dye that stain corresponding positions on the specimen for each pixel of the image; an element area identification unit that identifies an area of the cell constituent element based on the dye amount of the element identification dye; a condition setting unit that sets the presence or absence of the predetermined target molecule on the cell constituent element as a condition; and an extraction unit that extracts an area of a target portion that satisfies the condition based on the dye amount of the molecule target dye.

Microscope cell staining observation system, method, and computer program product

A microscope system includes a pigment amount calculating unit, a cell component identification processing unit, a target molecule expression portion extraction unit, a cell variant setting unit, a cell variant classification determining unit, and a display image generating unit. The pigment amount calculating unit calculates a pigment amount of a molecule target pigment for each pixel of a VS image. The cell component identification processing unit identifies a cell component based on the pigment amount. The target molecule expression portion extraction unit extracts expression portions of target molecules in the area of the cell component. The cell variant setting unit sets a cell variant including a combination of presence/absence of expressions of target molecules. The cell variant classification determining unit classifies a cell area in the VS image into a cell variant based on the combination of the expression portions of the target molecules included in the cell area.

Microscope system, specimen observing method, and computer-readable recording medium

A microscope system has a VS image generation means for generating a virtual slide image of a specimen which is constructed by mutually connecting a plurality of microscope images with a first photomagnification photographed and acquired whenever an objective lens and the specimen are relatively moved in a direction perpendicular to the optical axis and which represents the entire image of the specimen, an object-of-interest set means setting an object of interest with respect to the entire image of the specimen represented by the VS image, and a three-dimensional VS image generation means for generating a three-dimensional VS image which is constructed by connecting the microscope images at different focal positions in accordance with the same focal position and which is constructed from the microscope images with a second photomagnification higher than the first photomagnification and represents the image of the object of interest.

Microscope system, image generating method, and program for practicing the same

A whole specimen image generated in the bright view field observation method is displayed, and arbitrary domains are designated. And the fluorescence VS image of each object of interest is generated by acquiring the shape of microscopic image for every small block which is formed by dividing the inside of that object of interest into plurality for every said object of interest, and combining two or more microscopic images generated in the fluorescence observation method. The object of interest is an area where a tumor etc., exist, for example.

Microscope system and VS image production and program thereof

It is possible to provide a microscope system, capable of constructing a wide vision and high definition microscope image without requiring a work by a pathologist, of reducing a storage capacity for recording and storing after a pathologist observing and/or determining a diagnosis, and of forming and displaying a wide vision and high definition microscope image by comprising means for obtaining image information of the entirety, or a part, of a sample by moving an object lens and a sample relatively to each other in the perpendicular direction against an optical axis, means for designating a specific zone of the obtained image information, means for storing image information of the designated specific zone, means for reducing an information volume of image information not designated among the obtained image information, means for storing the reduced image information, and means for storing a positional relationship between these pieces of stored image information.

Microscope system, observation method and observation program

The microscopic image capture apparatus includes: a slide glass transfer unittransfers a slide glassfrom a first slide glass storage unitto a space under a microscope objective lensa wide field-of-view image capture unitcaptures the entire image of wide field-of-view of the slide glassin synchronization with the transfer of the slide glassby the slide glass transfer unita microscopic image capture unitcaptures a microscopic image of the sample S on the slide glasswhose entire image of wide field-of-view has been captured by the wide field-of-view image capture unitand a slide glass storage unitstores the slide glasswhose sample S has been captured by the microscopic image capture unitfrom the observation position of the microscopeinto the second slide glass tray unit

Microscopic image capture apparatus

The present invention is an automatic focal point detection device. In a broad visual field and high resolution observation, when focusing is impossible in a splitting visual field obtained by splitting a specimen in a visual field in plural number, a stage is moved to an in-focus position stored in advance and focusing is executed. Besides the device is provided with an excitation light shutter for intercepting an excitation light with which a specimen is irradiated and when stray light corresponding to a difference detected by closing and opening the shutter in fluorescence observation is smaller than a specific value, specimen search is performed and focusing is executed at a level exceeding stray light, while the difference is equal to or larger than the specific value, focusing is executed with nothing more done.

Growing community of inventors

Tokyo, Japan

Tatsuki Yamada