Canon Kabushiki Kaisha

Tatsuki Fukui

Tetsuya Yano

Takashi Kenmoku

Chieko Mihara

Ako Kusakari

Tsutomu Honma

Etsuko Sugawa

Norikazu Fujimoto

Takeshi Imamura

Shinya Kozaki

Masato Minami

Atsushi Takahashi

Kengo Kanazaki

Daisuke Sasaguri

Satoshi Yuasa

Takeshi Ikeda

Atsushi Tani

Fumio Yamauchi

Satoshi Ogawa

Fumiko Tomatsu

Tomohiro Suzuki

Tsuyoshi Nomoto

Kouichi Kato

Keigo Mizusawa

Akiko Tominaga

Shinzaburo Ito

Hiroyuki Aoki

Yoshinori Tomida

Hitoshi Itabashi

Hideo Saji

Akira Makino

Shigeki Yoshida

Sachiko Inoue

Mayuko Kishi

Kohei Sano

An object is to provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R represents any of a residue derived from a polymerization initiator, or a functional group; A may not be present, and when present, A represents any of a low-molecular compound, a dye, a reporter molecule, a target-binding molecule, a polymer or D; L represents a linker and L may not be present; nrepresents an integer of 1 or more; and D represents a dye backbone of a dye having absorption in the near-infrared region.

Conjugate of polysarcosine and NIR contrast agent for photoacoustic imaging

A photoacoustic device comprises a light source configured to generate first and second lights; an irradiation unit configured to generate a first acoustic wave from an object including a contrast agent by irradiating the object with the first light, and then bleach the contrast agent by irradiating the object with the second light and generate a second acoustic wave from the object by irradiating the object with the first light after bleaching; a receiving unit configured to output a first signal upon receiving the first acoustic wave and output a second signal upon receiving the second acoustic wave; and an acquisition unit configured to acquire first information based on the first signal, and acquire second information based on the second signal.

Photoacoustic device

To provide a compound having high T/B and a contrast agent for optical imaging. The compound has a molecular weight of a specific range, the compound in which two polyethylene glycols are bonded to a specific cyanine pigment through a linker. The present invention provides a compound which has a high T/B and which can be used as a contrast agent capable of imaging a tumor portion with high contrast.

Compound and contrast agent for optical imaging having the compound

A photoacoustic apparatus comprises a light source; an irradiation unit configured to radiate light from the light source to an object that contains a contrast agent; a receiving unit configured to receive acoustic waves generated when the contrast agent absorbs the light radiated by the irradiation unit and output an electrical signal; a correction processing unit configured to correct a signal strength of the electrical signal, based on a temporal change in a concentration of the contrast agent contained in the object; and an acquiring unit configured to acquire characteristics information on the object, based on the electrical signal that has been corrected by the correction processing unit.

Photoacoustic apparatus

The present invention provides contrast agents for photoacoustic imaging which exhibit high degrees of accumulation in tumor and low degrees of retention in the blood and can be administered into the blood. The contrast agents for photoacoustic imaging include a conjugate of a dye and a polyethyleneglycol represented by Formula (1), (5), (6), or (7) and an additive represented by Formula (301). 

Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same

A compound having a high tumor accumulation rate, or a salt thereof, and a contrast agent for optical imaging are provided. A compound having at least one specific organic dye covalently bound to polyethylene glycol, or a salt thereof is provided.

Compound or salt thereof and contrast agent for optical imaging

There is provided an ICG-loaded polymer nanoparticle that is dynamically stable, prevents the leakage of contained ICG and the resulting discoloration, and has a high molar absorbance coefficient. The particle contains a hydrophilic dye having a sulfonate group and a hydrophobic polymer, and the particle further contains at least one of a lipid having a positively charged region, a nicotinic acid derivative and a thiamine derivative.

Particle and contrast agent having the particle

The present invention provides a compound which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor. A compound produced by bonding of a polyethylene glycol and a specific cyanine based compound.

Compound and photoacoustic imaging contrast medium containing the compound

A method for producing a contrast agent includes the reaction step of allowing a cyanine dye containing a naphthyl group and a carboxyl or carboxylate group to react with a polyethylene glycol containing an amino group in an organic solvent to form a conjugate, and the purification step of purifying the conjugate using an organic solvent.

Method for producing contrast agent

Provided is a particle which can stably hold a dye in itself even in an aqueous solution such as serum, in order to solve such a problem of a particle containing ICG, which has been conventionally used in a contrast agent or the like, that the ICG is a dye having a hydrophilic functional group and hence the ICG leaks out of the particle in an aqueous solution such as serum. More specifically, provided is a particle including a hydrophobic dye having a cyanine structure, in which the hydrophobic dye is represented by the following chemical formula (1). 

Particle containing hydrophobic dye having cyanine structure, and contrast agent containing the particle

A particle includes a copolymer of lactic acid and glycolic acid, and at least one compound selected from silicon naphthalocyanine and derivatives of silicon naphthalocyanine, in which the particle has a particle size of 10 nm or more and less than 1000 nm.

Particles and contrast agent including the same for optical imaging

A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.

Contrast agent for photoacoustic imaging and photoacoustic imaging method

A resin for toner containing a resin component having both a polyester unit produced by polycondensation of a polyhydric alcohol component and a polycarboxylic acid component, and an aryl group having a sulfonic ester group as a substituent; and a toner that contains the resin for toner.

Resin for toner and toner

A polymer is provided in which a sulfonic group or a derivative thereof is introduced. The polymer includes a unit represented by the following chemical formula (1): 

Polymer having a sulfonic group or a sulfonate group and an amide group and method of producing same

A charge controlling agent is provided as a compound in which an amide group is introduced together with a sulfonic group or a derivative thereof. The charge controlling agent is characterized by including at least one compound represented by the chemical formula (2) in which an amide group is introduced together with at least one of a sulfonic group, a sulfonic acid ester, a sulfonic acid salt, and a sulfonic acid halide.

Growing community of inventors

Yokohama, Japan

Tatsuki Fukui