Kagawa University

Matsutani Chemical Industry Co., Ltd.

Rare Sugar Production Technical Research Laboratories, Llc.

Izumoring Co., Ltd.

Tatsuhiro Matsuo

Ken Izumori

Masaaki Tokuda

Kazuhiro Okuma

Tetsuo Iida

Kenji Morimoto

Satoshi Takamine

Tsuyoshi Shimonishi

Kaoru Takekawa

Tomonori Kimura

Noriko Hayashi

Takako Yamada

Problems Development of a process of producing inexpensive and safe hexose and compositions of the same. Means for Resolution A process of producing a sugar composition comprising a definite amount of an target hexose, comprising treating a starting liquid sugar material comprising a starting sugar material hexose or a mixture comprising hexose in a system in the presence of one or more types selected from the group consisting of basic ion exchange resins, alkalis and calcium salts to initiate an isomerization reaction as an equilibrium reaction to transform the starting sugar material hexose to the target hexose to prepare a sugar mixture comprising a definite amount of the target hexose and having a sugar constitution different from that of the starting sugar material, and hexose compositions containing D-allose and D-psicose and the use of the hexose compositions.

Process of producing sugar composition comprising D-psicose and D-allose via strong alkaline isomerization of D-glucose/D-fructose or alkaline pre-treatment of D-glucose/D-fructose followed by isomerization in the presence of a basic ion exchange resin

A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The composition is a composition in blend with D-psicose and/or a derivative thereof. The composition is in a form selected from sweeteners, seasonings, food additives, food materials, food and drink products, health food and drink products, pharmaceutical products, and feeds and blended with D-psicose, and/or a derivative thereof as the active component, for use in preventing and therapeutically treating diseases requiring the saving of insufficient insulin, the amelioration of insulin sensitivity and the amelioration of hyperglycemia, and/or diseases of which the symptoms can be ameliorated via the suppression of the abnormal intra-day increase of plasma glucose concentration or of which the onset can be prevented via the suppression thereof, such as diabetes mellitus, occult diabetic states, obesity, hyperglycemia, and/or arteriosclerosis. A method for using D-psicose in suppressing the abnormal intra-day increase of plasma glucose concentration, comprising giving D-psicose at given times to suppress the abnormal increase of plasma glucose concentration throughout the day.

Application of D-psicose to suppression of abnormal circadian increase in blood glucose level

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Kita-gun, Japan

Tatsuhiro Matsuo