Kissei Pharmaceutical Co., Ltd.

Kyorin Pharmaceutical Co., Ltd.

Tatsuhiro Kondo

Kazuya Tatani

Atsushi Kondo

Naohiro Kawamura

Yasushi Kohno

Tetsuro Tamai

Hideyuki Muranaka

Takehiro Ishikawa

Satoshi Akahane

Shigeki Seto

Tetsuya Nakamura

Junichi Kobayashi

Yuichiro Kai

Ritsu Suzuki

Tomonaga Ozawa

The present invention provides a compound represented by the general formula (I) of the present invention, which has EPreceptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Yrepresents a Calkylene group or the like; Yrepresents a single bond or the like; Z represents &#x2014;C(&#x2550;O)&#x2014;NHSOR, an acidic 5-membered hetero ring group, or the like; Rrepresents a hydrogen atom or the like; Rrepresents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; Rrepresents a halogen atom, a Calkoxy group, or the like; Rrepresents a hydrogen atom, a halogen atom, or the like; Rrepresents a hydrogen atom or the like; and Rrepresents a Calkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

Indole derivative and pharmacologically acceptable salt thereof

The present invention provides a compound represented by the general formula (I) of the present invention, which has EPreceptor antagonism: wherein A represents a pyridine ring, a furan ring, or the like; Yrepresents a Calkylene group; Yrepresents a single bond or the like; Rrepresents &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;SOR, an acidic 5-membered hetero ring group, or the like; Rrepresents an optionally substituted phenyl group, an optionally substituted 5-membered aromatic heterocyclic group, or the like; Rrepresents a halogen atom, a Calkoxy group, or the like; Rrepresents a hydrogen atom, a halogen atom, or the like; Rrepresents a hydrogen atom or the like; and Rrepresents a Calkyl group or the like], and a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.

Indole derivative, and pharmacologically acceptable salt thereof

A compound (I) of the present invention, which has an EPreceptor antagonism: 

Indole derivative or pharmaceutically acceptable salt thereof

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen or lower alkyl; R, R, Rand Rare each hydrogen, halogen, lower alkyl or lower alkoxy; Rand Rare each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; Ris &#x2014;C(O)&#x2014;R, -A-C(O)&#x2014;R, &#x2014;O-A-C(O)&#x2014;Ror a tetrazol-5-yl group, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof

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Niigata, Japan

Tatsuhiro Kondo