Kaken Pharmaceutical Company, Ltd.

Gene Techno Science Co., Ltd.

Tatsuhiro Harada

Akihiko Okuyama

Naoya Tsurushita

J Yun Tso

Shankar Kumar

Atsushi Matsuo

Satoru Ikegami

Noriyuki Kamei

Tomohiro Tanaka

Masanao Shimano

Makoto Haino

Yoichiro Hoshina

Yoshio Arakawa

Yoshiko Murakami

The present invention provides humanized antibodies that immunospecifically recognize human 9 integrin. Some of these antibodies inhibit the biological functions of the 9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with 9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.

Generation, expression and characterization of the humanized K33N monoclonal antibody

Reverse hydroxamic acid derivatives having specific structure represented by a general formula (Ia): (wherein A is a hydrogen atom or the like; Aris an arylene or the like; Aris an optionally substituted aryl, a heteroaryl or the like; Ris a hydrogen atom, an alkyl or the like; Ris a substituted cycloaryl, a heterocycloaryl or the like) and a general formula (I): (wherein A, Ar, Ar, and Rare the same as defined above and Ris an hydrogen atom, Ror the like) and salts thereof, which have TNF-&#x3b1; converting enzyme (TACE) inhibitory activity.

Reverse hydroxamic acid derivatives

A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C independently represents a hydrogen atom or a monovalent substituent; and X and X' independently represents a hydrogen atom or a monovalent substituent 

2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage

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Kyoto, Japan

Tatsuhiro Harada