Nippon Shinyaku Company, Ltd.

Tatsuhiko Kono

Hiroshi Enomoto

Yoshiaki Aoyagi

Yoshiaki Yoshikuni

Shoichi Chokai

Masahiro Yagi

Masao Murase

Tadatoshi Nomura

Kichiro Inoue

Masahiro Adachi

Hiromu Murai

Katsuya Ohata

Shingo Matsumura

Yukio Fujita

Haruo Tanaka

Masato Matsuda

Yoshitsugu Nomiyama

4-Quinolone derivatives of the present invention are useful for their anti-inflammatory, anti-allergenic, antitussive, expectorant and antithrombotic activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

4-quinolone derivatives having anti-inflammatory, anti-allergic,

4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.

Pharmaceutically active 4-hydroxy-3-benzoyl-2-quinolone derivatives

1-Substituted-9H-pyrido[3,4-b]indole derivatives, which are further optionally substituted in the 3- or 4-position, are inhibitors of xanthine-oxidase. A representative embodiment is 1-formyl-4-hydroxy-9H-pyrido[3,4-b]indole which can be prepared through the processing of Picrasma quassioides.

9H-Pyrido[3,4-b]indole derivatives

2-Hydroxymethyl-3,4,5-trihydroxypiperidine is obtained from the mulberry plant through extraction, optionally with further purification through ion exchange or chromatographic treatment.

Process for the isolation of 2-hydroxymethyl-3,4,5-trihydroxypiperidine

2-Hydroxymethyl-3,4,5-trihydroxypiperidine possesses antidiabetic and lipid biosynthesis inhibitory properties. The use of the compound for such indications and pharmaceutical compositions adapted to this use are described.

Method and composition for reducing blood glucose levels

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Suita, Japan

Tatsuhiko Kono