Hisamitsu Pharmaceutical Company, Inc.

Hisamitsu Pharmaceuticals

Tatsuaki Suzuki

Naruhito Higo

Tetsuro Tateishi

Munehiko Hirano

Takaaki Terahara

Masayoshi Maki

Hisakazu Kurita

Hideharu Chono

The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and adhesive layer, in which the drug containing adhesive layer firmly adheres onto the substrate and which gives no adhesion residue when applied to the skin and then peeled off. Namely, a patch comprising a substrate made of a polyester-based film and a drug-containing adhesive layer laminated thereon wherein the surface roughness (also known as 'the central line mean roughness' or 'Ra') of the polyester-based film surface in the side in contact with the adhesive layer is from 0.05 to 0.8 &#x3bc;m is provided.

Patch with improved anchoring properties between a substrate and an adhesive

Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm)and a have a very excellent skin permeability of the drug.

Preparations for percutaneous absorption

A device for perutaneous treatment by a serotonin receptor antagonist, comprising at least three layers including A) a drug-impermeable backing layer, B) a drug storage layer provided between the packing layer and a drug release layer and containing serotonin receptor antagonist, and C) a drug release layer constituted of a pressure-sensitive adhesive layer capable of controlling the release of a drug.

Transdermal preparation containing serotonin receptor antagonist

Tape formulation for percutaneous administration containing fentanyi

Growing community of inventors

Tsukuba, Japan

Tatsuaki Suzuki