Kowa Company Limited

Tatsuaki Nishiyama

Hiroyuki Ishiwata

Takeshi Doi

Toshiharu Morimoto

Masanori Ashikawa

Takahiro Kitamura

Junya Tagashira

Gen Watanabe

Akiyasu Koketsu

Masaki Yamabi

Syunji Takemura

Satoshi Goda

Hajime Yamada

Shunji Takemura

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R, R, R, Rand Rindependently represent a hydrogen atom, a Calkyl group, or the like; R, R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, or the like; A represents N&#x2014;R, a sulfur atom, or an oxygen atom; Rrepresents a hydrogen atom, a Calkyl group, or the like; B represents a Caryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R, R, R, Rand R' independently represent a hydrogen atom, a Calkyl group, or the like; R, R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, a Calkyl group, or the like; A represents N&#x2014;R, a sulfur atom, or an oxygen atom; Rrepresents a hydrogen atom, a Calkyl group, or the like; B represents a Caryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): (wherein, ring A represents a Caryl group or 5- to 10-membered heterocyclic group, X represents N&#x2014;R, a sulfur atom or an oxygen atom, R, R, R, Rand Rindependently represent a hydrogen atom, Calkyl group or Ccycloalkyl group, and R, Rand Rindependently represent a hydrogen atom or halogen atom), or a salt thereof, or a solvate thereof.

Fused piperidine compound and pharmaceutical containing same

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Tokyo, Japan

Tatsuaki Nishiyama