Russian-american Institute for New Drug Development

Tatiana A Voronina

James A Halikas

Arkady M Likhosherstov

Vitaly P Peresada

Sergei Borisovich Seredenin

Grigori G Rozantsev

Taisija L Garibova

Sergey B Seredenin

Rita U Ostrovskaya

Tatiana A Gudasheva

Gennady M Molodavkin

Alexander P Skoldinov

Sergei S Trophimov

A novel class of substances of N-acyl-prolyldipeptides, which possess psychotropic activity and particularly facilitate learning and memory are described. The N-acyl-prolyldipeptides of the invention have the formula: ##STR1## wherein R.sup.1 =(C.sub.4 -C.sub.5) alkyl, cycloalkyl, aralkyl, or aryl; R.sup.2 =H.sub.1 (C.sub.1 -C.sub.4) alkyl, carbamidoalkyl, or carbalkoxyalkyl; R.sup.3 =NH.sub.2, NH(alkyl), N(alkyl).sub.2, OH, or alkoxy; and n=0-3, preferably 0-2.

Biologically active n-acylprolydipeptides having antiamnestic,

1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives having the formula (Formula I) ##STR1## and therapeutically acceptable acid addition salts thereof (Formula I.HX), wherein: R.sup.1 =hydrogen or acyl groups; and R.sup.2 =hydrogen or substituted aminomethyl groups. Said compounds and their acid addition salts have psychotropic activity, particularly anxiolytic activity.

1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives

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Moscow, Russia

Tatiana A Voronina