Massachusetts Institute of Technology

Janssen Vaccines & Prevention B.v.

Kyoto University

Tasuku Kitada

Darrell J Irvine

Ron Weiss

Mariane Bandeira Melo

Ronald Vogels

Ely Blanton Porter

Marijn Van Der Neut Kolfschoten

Hirohide Saito

Kei Endo

Yuan Zhang

Maria Hottelet Foley

Liliana Wroblewska

Tyler Wagner

Jacob Becraft

Katie Bodner

Velia Siciliano

Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.

Methods and compositions for heterologous repRNA immunizations

Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.

RNA-based logic circuits with RNA binding proteins, aptamers and small molecules

Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.

Lipid nanoparticles and use thereof to deliver RNA polynucleotides

Growing community of inventors

Ghent, Belgium

Tasuku Kitada