Centre for Cellular and Molecular Platforms

Centre for Cellular and Molecular Platforms (c-camp)

Indian Institute of Technology Madras

Taslimarif Saiyed

Sudip Mondal

Murumalla Ravi Kumar

H Krishnamurthy

Aravinda K Chavalmane

Anil Prabhakar

Janhavi Pandurangi

Ravi Manjithaya

Suresh Santhi Natesan

Shashank Rai

A method of inhibiting neuroinflammation in neuron surrounding cells, includes a step of treating the neuron surrounding cells with at least one tyrosine kinase inhibitor or sirtuin-2 inhibitor or a combination thereof, to inhibit the neuroinflammation. A method of managing neuroinflammation or neuroinflammation mediated neurodegenerative disease or disorder in a subject in need thereof, includes administering at least one tyrosine kinase inhibitor or sirtuin-2 inhibitor or a combination thereof to the subject. A composition includes at least one tyrosine kinase inhibitor or at least one sirtuin-2 inhibitor optionally along with pharmaceutically acceptable excipient.

Methods and compositions for managing neuroinflammation and neurodegeneration

The present disclosure is related to a microfluidic flow analyzer for pathological detection. The microfluidic flow analyzer comprises plurality of buffer channels, sample channel, central flow channel, plurality of exciting optical channels and plurality of receiving optical channels. The plurality of exciting optical channels and the plurality of receiving optical channels are placed at predetermined angle to the central flow channel. The plurality of exciting optical channels excite cell in the sample solution flowing through the central flow channel. The cell being excited produces one or more optical signals. The one or more optical signals are received by the plurality of receiving optical channels. The microfluidic flow analyzer comprises plurality of detectors placed on each of the plurality of receiving optical channels for detecting one of the one or more optical signals. The detected optical signal is sent to a computing unit for pathological detection.

Microfluidic-based flow analyzer

Growing community of inventors

Bengaluru, India

Taslimarif Saiyed