Council of Scientific and Industrial Research

Taruna Madan

Puranam Usha Sarma

Wahajul Haq

Shweta Saxena

Puranam U Sarma

Priyanka Priyadarsiny

Seturan B Katti

Lakshna Mahajan

Uday Kishore

The present invention provides the use of formulation with surfactant protein-D (SP-D) in the modulation of activity of human eosinophils derived from hypereosinophilic patients to an increased activation state and increased apoptosis. Accordingly the utility of the invention can be extended in human subjects in resolution of eosinophilic inflammations in related diseases and disorders like neuromuscular and respiratory diseases with eosinophilia other than airway-hyperresponsiveness, allergy and asthma, hypereosinophilic leukemias, hypereosinophilc syndromes (rare hematological diseases), skin diseases like eosinophilia-Myalgia syndrome, eosinophilic fascitis, capillary leak syndromes (IL-2), Churg-Strauss syndrome, toxic oil syndrome, parasitosis, etc., where a large number of stimulated eosinophils accumulate and release a series of growth factors, cytokines, chemokines, bioactive lipid mediators, toxic oxygen metabolites.

Human lung surfactant protein, SP-D, modulates eosinophil activation and survival and enhances phagocytosis of apoptotic bosinophils

The invention provides a method for predicting the susceptibility of an individual to pulmonary tuberculosis, the method comprising amplifying genomic DNA of pulmonary tuberculosis patients and normal control individuals using oligonuecleotide primers, sequencing the amplified PCR product and identifying the sequence variation computationally by comparing it with the already existing sequence of human SP-A2 gene.

Method of detection of SP-A2 gene variants

Allele specific primers and probes suitable for detecting allelic variants of human SP-A2 gene for applications such as molecular diagnosis, prediction of an individual's susceptibility, and/or the genetic analysis of SP-A2 gene in a population.

Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis

The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen offrom aa 6-22, comprising aa 10-20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from the modification by substitution and/or by addition and/or deletion of one or more amino acid altering specified properties.

Polypeptides useful for diagnosis of Aspergillus fumigatus and a process of preparing the same

The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen of,from aa 6-22, comprising aa 10-20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from the modification by substitution and/or by addition and/or deletion of one or more amino acid altering specified properties.

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Delhi, India

Taruna Madan