Amgen Inc.

Taruna Arora Khare

Kenneth William Walker

Shaw-Fen Sylvia Hu

Francis Hall Martin

Leslie Phillip Miranda

John Kevin Sullivan

Hung Q Nguyen

Colin Victor Gegg, Jr

Beverly S Adler

Joseph G McGivern

Disclosed is a composition of matter comprising a ShK toxin peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression

Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

Methods of using conjugated toxin peptide therapeutic agents

Conjugated toxin peptide therapeutic agents

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Thousand Oaks, CA, United States of America

Taruna Arora Khare